微小RNA在口腔扁平苔藓中的作用  

Function of microRNAs in oral lichen planus

作　　者：刘佳佳[1] 吴圆琴 曾昕[1] 周瑜[1] 

机构地区：[1]口腔疾病研究国家重点实验室华西口腔医院黏膜科(四川大学),成都610041

出　　处：《国际口腔医学杂志》2015年第1期48-53,共6页International Journal of Stomatology

基　　金：国家自然科学基金(81470747;81102060);高等学校博士学科点专项科研基金(20110181120068;20110181110055)

摘　　要：微小RNA家族在调控基因表达中的重要作用日益受到关注,其调控的基因涉及细胞增殖、凋亡、生长、分化和代谢、血管化和免疫应答等多种生物过程,其表达谱和表达量的变化与多种疾病如肿瘤、炎症性疾病、自身免疫性疾病的发生、发展密切相关。本文对口腔扁平苔藓中微小RNA的研究现状作一综述。MicroRNAs（miRNAs） have attracted increasing attention because of their important roles in regulating gene expression. Gene regulation by miRNAs is involved in various biological processes, such as cell proliferation, apoptosis and metabolism, growth, differentiation, vascularization, and immune response. The expression spectrum and changes of miRNAs are closely related to the occurrence and development of various diseases, such as tumor, inflammatory diseases, and autoimmune diseases. This article reviews the current research statuses of miRNAs in oral lichen planus.

关 键 词：微小RNA 自身免疫性疾病 口腔扁平苔藓 

分 类 号：R781.5[医药卫生—口腔医学]