慢性应激引起的大鼠海马神经细胞形态结构的改变  

The pathological change in the neurons of hippocampus of rat after chronic unpredictable mild stress

作　　者：林志雄[1] 殷静雯[1] 罗旭东[1] 

机构地区：[1]广东医学院附属医院精神心理科,广东湛江524001

出　　处：《广州医学院学报》2014年第3期14-16,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨慢性应激引起的抑郁样行为与海马神经细胞形态结构的变化。方法:建立慢性轻度不可预见性应激大鼠抑郁模型,检测大鼠快感缺乏,行为活动减少,体质量减轻等抑郁样症状,观察海马区病理改变。结果:实验组和对照组大鼠行为学评分存在显著差异(P<0.01),实验组海马椎体细胞萎缩,神经细胞层数减少,细胞数目明显减少(P<0.01)。结论:应激可导致大鼠抑郁样行为的发生,同时影响神经细胞的生长和存活。Objective：To identify The Change in the neurons of Hippocampus of Rat and depressive-like behavior after Chronic Unpredictable Mild Stress （ CUMS）. Method： The mice were subjected to various unpredictable stressors during the 21 days CUMS procedures. The depressive-like behavior and pathological change was observed.Results：The number of neurons of hippocampus after stress was significantly different （P〈0.01）. Conclusion： Rats after chronic unpredictable mild stress appeared depressive-like behavior correlated with decreased of neurons hippocampus.

关 键 词：抑郁障碍 慢性轻度不可预见性抑郁模型 海马 

分 类 号：R575.2[医药卫生—消化系统]