星瑙灵治疗轻中度焦虑症抑郁症的随机对照开放研究  

A Randomized Clinical Trial on Antianxiety and Antidepression Effects of Seniovita

作　　者：高波廷[1] 姜亚平[1] 徐金枝[1] 胡晓晴[1] 魏银秀 杨渊[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030 [2]华中科技大学同济医学院附属同济医院高干科,武汉430030

出　　处：《神经损伤与功能重建》2014年第6期485-487,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:观察星瑙灵片治疗轻中度焦虑症、抑郁症的疗效与安全性。方法:322例轻中度焦虑症、抑郁症患者随机分为星瑙灵组162例和对照组160例,星瑙灵组口服星瑙灵片,每次2片,一日3次;对照组口服氟哌噻吨美利曲辛片,每次1片,每日2次。疗程均为8周。于治疗前和治疗后第2、4、6、8周分别以汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评估疗效。结果:治疗2周后,2组的HAMA评分和HAMD评分均明显下降(P<0.05),2组间差异无统计学意义(P>0.05)。治疗8周后,星瑙灵组的显效率和治愈率与对照组比较差异无统计学意义(P>0.05)。结论:星瑙灵治疗轻中度焦虑症、抑郁症安全有效。Objective：To evaluate the efficacy and safety of Seniovita coated tablets in the treatment of the pa-tients with mild and moderate anxiety and/or depression . Methods：A total of 322 patients with mild and moderate anxiety and/or depression were randomly divided into Seniovita group （n=162） and control group （n=160） . The Seniovita group was orally given Seniovita （2 tablets, tid）, and the controlled group was orally given Deanxit （1 tablet, bid）. The efficacy of the 2 groups were evaluated with Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale （HAMD） before and 2, 4, 6, 8 week after the treatment. Results：There was a significant decline in HAMA score and HAMD score in the 2 groups at 2nd week after treatment （ 〈0.05）. There was no significant difference between the 2 groups in HAMA score and HAMD after the treatment （ 〉0.05）. At 8th week after the treatment, there was no significant difference between the 2 groups in the obvious effective rate and the curative rate. Conclusion：Seniovita coated tablet is safe and effective in treating anxiety and depression.

关 键 词：星瑙灵 氟哌噻吨美利曲辛片 焦虑症 抑郁症 随机对照临床试验 

分 类 号：R741[医药卫生—神经病学与精神病学] R749.05[医药卫生—临床医学]