帕罗西汀联合白脉软膏治疗慢性紧张型头痛的临床疗效  

Clinical Effect of Paroxetine Combined with Baimai Recipe on the Treatment of Patients with Chronic Tension-type Headache

作　　者：周昊[1] 徐蕾[1] 王暖[1] 黄红莉[1] 

机构地区：[1]江苏省徐州市第一人民医院神经内科,江苏徐州221002

出　　处：《神经损伤与功能重建》2014年第6期488-491,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:观察帕罗西汀联合白脉软膏治疗慢性紧张型头痛(CTH)的临床疗效。方法:CTH患者60例,随机分为给予帕罗西汀联合安慰剂软膏治疗的对照组和给予帕罗西汀联合白脉软膏治疗的观察组各30例,疗程8周。比较治疗前后患者外感受抑制实验(ESP)的第二潜伏期(ESP2)、时限及肌电频率、波幅变化,评价头痛程度、焦虑抑郁情绪及生活质量。结果:治疗后2组EPS2潜伏期明显缩短,时限明显延长(P<0.05),观察组较对照组更明显(P<0.05)。对照组肌电频率和波幅改变不明显(P>0.05),观察组肌电频率和波幅明显降低(P<0.05)。2组头痛程度、焦虑抑郁情绪评分明显低于治疗前,生活质量评分明显高于治疗前(P<0.05),观察组较对照组更明显(P<0.05)。结论:帕罗西汀联合白脉软膏治疗CTH疗效优于单用帕罗西汀。Objective：To observe the clinical effect of Paroxetine combined with baimai recipe on the treatment of chronic tension-type headache （CTH）. Methods：Sixty CTH patients were randomly divided into observation group treated with Paroxetine combined with baimai recipe and control group treated with Paroxetine combined with placebo recipe（n=30） with the course of treatment of 8 weeks. The second latency （ESP2）, time limit, electromyo-gram frequency and amplitude variation of exteroceptive suppression experiment （ESP） in patients before and after treatment were measured. The emotion and quality of life of headache severity, anxiety and depression were evalu-ated. Results：The patients in the two groups presented significantly decreased EPS2 latency and prolonged time limit after treatment compared with those before treatment （ 〈0.05）. The electromyogram frequency and amplitude had no obvious change in control group, which showed obvious reduction in observation group. The headache degree and anxiety and depression score was significantly lower and the quality of life score was significantly higher than those before treatment （ 〈0.05）. After the treatment, the ESP2 latency and time limit in the observation group were shorter than the control group （ 〈0.05）. The headache degree and anxiety and depression score was significantly lower in the observation group than that of the control group （ 〈0.05）. The quality of life score was significantly higher in the observation group than that in the control group （ 〈0.05）. Conclusion：The clinical effect of Paroxetine combined with baimai was better than that using a single Paroxetine in the treatment of CTH.

关 键 词：帕罗西汀 白脉软膏 慢性紧张型头痛 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]