细胞质膜及内膜酸化作用的调控及意义  

Regulation and significance of acidification of plasma membrane and intracellular membranes

作　　者：胡海滢[1] 刘伟敬[1] 刘华锋[1] 

机构地区：[1]广东医学院附属医院肾病研究所,湛江医学硕士研究生524000

出　　处：《医学研究生学报》2014年第11期1223-1225,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81270798)

摘　　要：真核细胞内细胞器的酸性环境是内吞作用、溶酶体酶分泌等生理活动的重要条件,液泡三磷酸腺苷酶(vacuolar ATPases,V-ATP)和氯离子通道(chloride channel,CLC)家族在真核细胞内各种膜性结构及质膜上广泛分布,它们参与和调节囊泡内的酸化作用,文章对V-ATP酶和CLC蛋白的分布、结构、作用机制及生理病理意义作一综述。Acidic environment of organelles of eukaryotic cells plays an important role in endocytosis, the secretion of lysoso-mal enzymes and other physiological activities.V-ATPase （vacuolar ATPases） and CLC （chloride channel） family are widely distribu-ted and present in virtually all eukaryotic cells in intracellular membranes and in the plasma membrane.They are responsible for the a-cidification of the vesicular interior.In this paper, the distribution, structure, mechanism of action and physiological and pathological significance of V-ATPase and CLC protein are discussed.

关 键 词：液泡三磷酸腺苷酶 氯离子通道 酸化作用 

分 类 号：R36[医药卫生—病理学]