溃疡性结肠炎合并肠道菌群失调的临床研究  

Clinical research of ulcerative colitis combind with gut microflora imbalance

作　　者：刘玲[1] 王鑫[1] 朱祖安[1] 

机构地区：[1]徐州医学院附属医院消化内科,江苏徐州221000

出　　处：《胃肠病学和肝病学杂志》2014年第11期1299-1301,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究抗生素的应用对溃疡性结肠炎(ulcerative colitis,UC)患者肠道菌群的影响。方法 60例UC患者按照近1个月内是否应用抗生素分为抗生素组(40例)和非抗生素组(20例),入院后第2天按照《全国临床检验操作规程》行大便肠道菌群检测。结果抗生素组正常菌群5例,I度菌群失调8例,Ⅱ度菌群失调17例,Ⅲ度菌群失调10例;非抗生素组大便检验为正常菌群13例,Ⅰ度菌群失调4例,Ⅱ度菌群失调3例,Ⅲ度菌群失调0例。抗生素组UC患者肠道菌群失调发生率较非抗生素组明显增加,差异有统计学意义(P<0.05)。结论抗生素应用使UC患者发生肠道菌群失调的风险增加。Objective To investigate the effect of antibiotic on the intestinal microbiota of patients with ulcerative colitis （UC）.Methods Sixty UC patients were divided into antibiotic group and non-antibiotic group according to the application of antibiotics or not during last month.Fecal coccus-bacillus ratio test was conducted referring to the National Guide to Clinical Laboratory Procedures two days after admission.Results The fecal coccus-bacillus ratio in the antibiotic group,5 cases were normal,8 cases were Ⅰ degree dysbacteriosis,17 cases were Ⅱ degree dysbacteriosis,10 cases were Ⅲ degree dysbacteriosis.The fecal coccus-bacillus ratio in the non-antibiotic group,13 cases were normal,4 cases were Ⅰ degree dysbacteriosis,3 cases were Ⅱ degree dysbacteriosis,there was no Ⅲ degree dysbacteriosis.In the antibiotic group of UC patients,the incidence rate of the disorder in intestinal flora obviously increased than that of the nonantibiotic group （P ＜ 0.05）.Conclusion The application of antibiotics has a significant effect on the intestinal microbiota of patients with UC.

关 键 词：溃疡性结肠炎 肠道菌群失调 抗生素 

分 类 号：R574.1[医药卫生—消化系统]