蓬莱市发热伴血小板减少综合征监测分析  

Monitoring and analysis of severe fever with thrombocytopenia syndrome in Penglai City

作　　者：周淑琴[1] 李俊荣[1] 孟淑欣 纪经海[1] 刘姗姗[1] 丁淑军[2] 王显军[2] 

机构地区：[1]蓬莱市疾病预防控制中心,山东蓬莱265600 [2]山东省疾病预防控制中心

出　　处：《实用预防医学》2014年第11期1287-1290,共4页Practical Preventive Medicine

基　　金：国家自然科学青年基金项目(81102171);山东省医药卫生科技发展计划(2011HZ055);山东省科学技术发展计划(2012GHZ30031)

摘　　要：目的研究蓬莱市发热伴血小板减少综合征（简写SFTS）流行病学特征和感染状况,为制定防控策略提供科学依据。方法对2010-2013年蓬莱市发热伴血小板减少综合征病例采用描述性流行病学方法,分析其流行病学特点,用间接法ELISA对病例地区1 525名蓬莱市民的血清进行SFTSV-Ig G抗体检测,采集病例地区动物宿主血清标本通过双抗原夹心法ELISA进行SFTSV的总抗体检测,通过Realtime RT-PCR进行SFTSV的核酸检测。结果 2010-2013年蓬莱市发热伴血小板减少综合征病年均发病率为4.55/10万,死亡率0.89/10万,病死率为19.51%,病例覆盖全市9.57%村社区,病例以农民为主,6-9月为高发季节,年龄以40~79岁为主。蓬莱市健康人群SFTSV-Ig G阳性率为9.05%,动物宿主牛、羊、跑山鸡、狗、猪和圈养鸡、抗体阳性率分别为63.86%、44.76%、42.31%、31.46%、6.96%和6.00%。结论蓬莱市是发热伴血小板减少综合征病流行地区,存在着新型布尼亚病毒隐性感染情况,牛羊狗可能是病毒主要的动物宿主。Objective To study the epidemiological characteristics and infection situation of severe fever with thrombocytopenia syndrome （SFTS） so as to provide a scientific basis for formulating prevention and control strategies. Methods Epidemiolo- gical characteristics of SFTS cases in Penglai City from 2010 to 2013 were analyzed by descriptive epidemiological method. SFTS virvs IgG （SFTSV- IgG） antibody titers in sera from 1,525 Penglai citizens in the case region was proceeded using indirect ELISA. Sera from animal hosts in the case region were collected. A novel double antigen sandwich ELISA was conducted to de- tect the overall antibodies to SFTSV, and realtime RT - PCR was employed to detect DNA of SFTSV. Results The average annual incidence rate of SFTS in Penglai City during 2010 - 2013 was 4.55/100,000, with the death rate of 0.89/100,000 and the mortality rate of 19.51%. The cases distributed in 9.57 % of the villages and communities. Most patients were farmers aged between 40 and 79 years, and the period of high incidence was druing June through September. The SVI＇SV- IgG positive rate among healthy population in Penglai City was 9.05 %, and the positive rates among host animals, like oxen, sheep, pheasants, dogs, pigs and farm-reared chicken, were63.86%, 44.76%, 42.31%, 31.46%, 6.96% and6.00%, respectively. Con- clusions Penglai City is the epidemic area of SFTS; moreover, there exists latent infection of novel bunyavims. Oxen, sheep and dogs may be the major animal hosts of the SFTSV.

关 键 词：发热伴血小板减少综合征 SFTSV IG G抗体 

分 类 号：R181.8[医药卫生—流行病学]