氟他胺致亚急性肝衰竭一例并文献复习  

Subacute Liver Failure Induced by Flutamide ： One Case Report and Literature Review

作　　者：林吓聪[1] 李金雨[1] 韩聪祥[1] 于忠英[1] 谢智明[1] 

机构地区：[1]中国人民解放军第175医院暨厦门大学附属东南医院泌尿外科,福建漳州363000

出　　处：《医学临床研究》2014年第10期1959-1961,共3页Journal of Clinical Research

摘　　要：【目的】探讨氟他胺致药物性肝损伤的发生机制及药理学特点，提高对该药物不良反应的认识及处理措施。【方法】报告1例前列腺癌患者内分泌治疗过程中氟他胺引起的严重药物不良反应一亚急性肝衰竭的临床资料，复习相关文献进行讨论。【结果】患者服用氟他胺三个月左右出现乏力、尿黄、全身黄染等表现，经停用氟他胺并积极降酶、保肝等治疗后肝功能逐渐恢复正常。【结论】虽然氟他胺引起肝损伤的发生率不高，但临床医师一定要关注该药潜在的肝毒性，一旦确诊药物性肝损伤，立即停用并做出相应处理。[Objective] To explore the mechanism and pharmacological characteristics of flutamide-induced liver injury in order to increase the awareness and treatment of drug adverse reaction. [Methods] Clinical data of 1 patient with severe adverse drug reaction-subacute liver failure induced by flutamide during endocrine therapy for prostate cancer was reported. The relevant literature was reviewed and discussed. [Results] The patient had symptoms such as fatigue, dark urine and jaundice after flutamide was given about 3 months. Liver function gradually returned to normal after flutamide withdrawal and then taking active enzyme-lowering and liver protection treatment. [Conclusion]Although the incidence of flutamide-induced liver injury is low, but clinicians must pay attention to its potential hepatotoxicity. Once drug-induced liver injury is diagnosed, the drug should be discontinued immediately and the appropriate treatment should be taken.

关 键 词：前列腺肿瘤/药物疗法 氟他胺/副作用 肝功能衰竭/病因学 

分 类 号：R575.3[医药卫生—消化系统]