抵抗素样分子-α研究的新进展  

Progress in the study of resistin-like molecule-α

作　　者：刘桂林[1] 蒙臣 张诗海[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022

出　　处：《国际麻醉学与复苏杂志》2014年第12期1141-1143,1147,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景抵抗素样分子-α（resistin-like molecule alpha，RELM-α）又称为FIZZ1（found in inflammatory zone 1），是近年来新发现的分泌型细胞因子。研究表明RELM-α具有多种生理作用，参与许多疾病的发生发展过程。目的通过综述的方式对RELM-α的生理作用和机制进行系统的阐述，为以后的研究提供参考，引导新的研究领域。内容基于目前RELM-α的研究进展，一方面总结了RELM-α具有多种生理功能，另一方面阐述了RELM-α的作用机制。趋向RELM-α已得到越来越多的学者关注，目前关于RELM-α与肺相关疾病研究较多，其在其他疾病中发挥的作用及作用机制研究较少，具有广阔的研究前景。Background Resistin-like molecule-α （RELMα） known as found in inflammatory zone 1 （FIZZ1） has been found to be a new type of secretory cytokine in recent years. The studies have showed that RELM-α has many physiological functions and is involved in development of many diseases. Objective To review the physiological actions and mechanism of RELM-α to provide a reference for further research and to inspire new research fields. Content This article is based on the current research progress. RELM-α was summarized mainly from two aspects： the various physiological functions and its mechanism of action. Trend RELM-α has raised more and more researchers＇ concerns. More studies focus on RELM-q related pulmonary diseases, but less on its roles in other diseases and mechanism of action. So it has a wide research prospect.

关 键 词：抵抗素样分子 细胞因子 缺氧 炎症 凋亡 血管收缩 

分 类 号：R364[医药卫生—病理学]