抗CCP抗体在类风湿性关节炎诊断中的应用进展  

Progress of anti-CCP antibody in the application of diagnosis of rheumatoid arthritis

作　　者：梁海[1,2] 吴久鸿[2] 向卓[2] 张学辉[2] 

机构地区：[1]安徽医科大学研究生学院,合肥230032 [2]解放军第306医院药学部,北京100101

出　　处：《中国骨质疏松杂志》2014年第11期1375-1378,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目赞助课题(No.81072546)

摘　　要：目前类风湿关节炎的诊断检查有炎性标志物(包括血沉和C反应蛋白)检测,免疫复合物和补体检测,关节滑液检测以及自身抗体检测。这些指标经常伴随类风湿关节炎的活动而改变,早期诊断主要依靠的是自身抗体检测。抗环瓜氨酸肽(cyclic citrullinated peptide,CCP)抗体是一种抗角蛋白抗体,在类风湿性关节炎的敏感度和特异度较类风湿因子高。发病一年内,类风湿性关节炎患者大部分血清中可检测到抗CCP抗体的存在,同时抗CCP抗体阳性也可以用来预测严重破坏的类风湿性关节炎。因此,抗CCP抗体对于类风湿性关节炎的早期诊断及预后评估是极有帮助的。本文综述了近年来抗CCP抗体对于诊断类风湿关节炎的应用进展。Currently the markers for the diagnosis of rheumatoid arthritis include inflammatory makers （ including blood sedimentation and C-reactive protein） , immune complexe and complement detection, detection of joint synovial fluid, and detection of autoantibodies.These indicators change with the activity of arthritis.Early diagnosis relies mainly on detection of autoantibodies. Anti-cyclic citrullinated peptide antibody（ anti-CCP） is a kind of anti-keratin antibody, having higher sensitivity and specificity than the rheumatoid factor in diagnosis of rheumatoid arthritis.During the first year of rheumatoid arthritis, the existence of anti-CCP can be detected in the serum of most of these people.Positive anti-CCP can also be used to predict serious damage.Therefore, anti-CCP is extremely helpful in early diagnosis and prognosis assessment of rheumatoid arthritis.In this paper, the recent application of anti-CCP in the diagnosis of rheumatoid arthritis is reviewed.

关 键 词：抗CCP抗体 类风湿性关节炎 类风湿因子 

分 类 号：R593[医药卫生—内科学]