sCTLA-4与CD4+CD25+调节性T细胞的相关性及其与肿瘤的关系  

The correlation between s CTLA-4 and CD4 + CD25 + regulatory T lymphocyte and its relationship with tumor

作　　者：谢荃沁 蒋敬庭[1] 吴昌平[1] 

机构地区：[1]苏州大学附属第三医院肿瘤中心,江苏常州213003

出　　处：《临床肿瘤学杂志》2014年第11期1038-1042,共5页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(30972703;81171653);江苏省自然科学基金资助项目(BK2011246;BK2011247);江苏省卫生厅医学科技发展基金资助项目(P200932;P200933);常州市社会发展计划基金资助项目(CS20092019;CS20102020)

摘　　要：调节性T细胞(Treg)在保持免疫反应平衡、调节免疫反应中有重要作用。转录因子Foxp3被认为是Treg细胞的标志性分子。在恶性肿瘤中,Treg被认为参与了宿主免疫系统的肿瘤免疫逃避,与不同肿瘤患者较差的生存结局有关。细胞毒性T淋巴细胞相关抗原4(CTLA-4)表达于激活的T细胞,在T细胞免疫反应中起负向调控作用。CTLA-4还能以溶解形式(s CTLA-4)存在于机体循环中,调节免疫环境稳定。CTLA-4和Treg功能上的重叠共同影响了免疫调节过程,其相互作用尚有待研究。Regulatory T lymphocytes （Treg） play an important role in immune balance and immune regulation. Foxp3 is a symbolic molecule of regulatory T ceils. Treg is considered to take part in tumor immune escape in host immune system, and is associat- ed with poor survival outcome in a variety of cancers. Cytotoxic T lymphocyte-associated antigen-4（CTLA-4） is expressed on activated T cells, and has negative control response in T cell immune response. CTLA-4 can also exist in organism circulation as a soluble form （ sCTLA-4）, and is involved in immunological homeostatic control. CTLA-4 and Treg overlap in functions, and affect the immune regu- lation process together, but the mechanism of interaction is an area for further study.

关 键 词：细胞毒性T淋巴细胞相关抗原4 调节性T细胞 肿瘤治疗 

分 类 号：R730.3[医药卫生—肿瘤]