丁苯酞软胶囊治疗椎动脉优势型眩晕疗效观察  

Clinical efficacy of dl-3-butylphthalide soft capsules in treatment of vertigo caused by vertebral artery dominance: a randomized controlled trial

作　　者：阳娜[1] 谭利明[2] 杨利[2] 周仕钧[1] 唐海洋[1] 

机构地区：[1]湘潭市第一人民医院神经内科,湖南省湘潭市411100 [2]中南大学湘雅二医院神经内科,湖南省长沙市410011

出　　处：《国际神经病学神经外科学杂志》2014年第5期430-432,共3页Journal of International Neurology and Neurosurgery

摘　　要：目的观察丁苯酞软胶囊治疗椎动脉优势型后循环缺血性眩晕的疗效及安全性。方法收集首次发作眩晕并行MRA检查证实一侧椎动脉优势的后循环缺血患者76例为研究对象,随机分为治疗组和对照组,对照组给予阿司匹林加阿托伐他汀钙片基础治疗,治疗组在对照组的基础上加用丁苯酞软胶囊,治疗14 d后观察眩晕缓解程度、TCD血流异常率变化。结果治疗组总有效率92.1%,对照组总有效率65.8%,两组比较差异有统计学意义P<0.05)。两组经治疗后基底动脉TCD异常率均有下降,其中治疗组(47.4%)与对照组(57.9%)相比较下降更明显,差异有统计学意义(P<0.05)。结论丁苯酞软胶囊治疗椎动脉优势型眩晕有显著疗效且安全。Objective To evaluate the clinical efficacy and safety of dl-3-butylphthalide（ NBP） soft capsules in the treatment of posterior circulation ischemia vertigo（ PCIV） due to the hemodynamic effect of one dominant vertebral artery. Methods Seventy-six patients with the first onset of vertigo were selected,among whom PCIV was detected by head magnetic resonance angiography. The PCIV patients were randomly assigned to treatment and control groups,which were given aspirin and atorvastatin calcium therapy and NBP soft capsules combined with aspirin and atorvastatin calcium therapy,respectively. The degree of symptom alleviation and the rate of abnormal transcranial Doppler（ TCD） blood flow were measured after 14 days of treatment. Results The overall response rates were 92. 1% in the treatment group and 65. 8% in the control group,showing a significant difference between groups（ P 0. 05）. The rate of abnormal TCD flow findings in basilar artery decreased in both groups after treatment,and the decrease was higher in the treatment group than in the control group（ 47. 4% vs 57. 9%,P 0. 05）. Conclusions Use of NBP soft capsules is an effective and safe therapy for PCIV caused by vertebral artery dominance.

关 键 词：丁苯酞 椎动脉优势 眩晕 后循环缺血 

分 类 号：R741[医药卫生—神经病学与精神病学]