转基因生物对肠道微生物影响的研究进展  

Research Progress in the Intestinal Health About Genetically Modified Organisms

作　　者：元延芳[1,2] 邹世颖[1,3] 郎天琪 徐国建 贺晓云[1,3] 黄昆仑[1,3] 

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083 [2]北京资源亚太饲料科技有限公司,北京102600 [3]农业部转基因生物食用安全监督检验测试中心,北京100083

出　　处：《农业生物技术学报》2014年第12期1561-1566,共6页Journal of Agricultural Biotechnology

基　　金：国家转基因生物新品种培育重大专项(No.2014zx08011-005)

摘　　要：肠道微生物平衡对于维持机体的生理平衡发挥重要作用,与宿主的营养代谢、免疫调节有着重要的关系。肠道健康直接反映机体的健康状态。外源物质可通过肠道菌群、肠壁通透性、粘膜免疫、肠道代谢物等影响机体健康。对转基因生物进行肠道健康的安全评价可以监测转基因生物通过肠道产生的非期望效应,为转基因生物的安全性提供有力保证。本研究汇总了近年来国内外对转基因生物在肠道微生物平衡方面的研究,完善了非期望效应的评价内容,在一定程度上也进一步完善了转基因生物安全评价体系。The gastrointestinal microflora play an important role in maintaining the physiological balance, and has an important relationship with nutrition metabolism, immune regulation of host. The gastrointestinal health reflects the body’s health directly. Exogenous substances may influence the gastrointestinal health by altering intestinal microflora, intestinal permeability, mucosal immunity, intestinal metabolites. Safety assessment of gastrointestinal health about genetically modified organisms （GMOs） is used to monitor the unintended effect, which provides guarantee to the safety of GMOs. This paper summarized the researches on the unintended effect of gastrointestinal health caused by GMOs. The safety assessment of gastrointestinal health will continuously improve and perfect the system of safety assessment of GMOs.

关 键 词：肠道健康 转基因生物 安全评价 

分 类 号：S828.5[农业科学—畜牧学]