贞芪扶正颗粒联合替吉奥胶囊治疗老年人晚期贲门癌的临床研究  

Clinical research of Zhenqifuzheng granule combined with Tegafur gimeracil oteracil potassim capsule in treating advanced carcinoma of gastric cardia in aged patients

作　　者：李科[1] 张旭[1] 

机构地区：[1]南京中医药大学江苏省中医药防治肿瘤协同创新中心,210023

出　　处：《中华老年医学杂志》2014年第12期1314-1316,共3页Chinese Journal of Geriatrics

基　　金：欧盟第七框架项目（PIRSES-GA-2013-612589）;江苏省高校优势学科建设工程资助项目（PAPD）资助;江苏省自然科学基金（BK20131415）;科技部十一五支撑计划（2006BAI11B08-01）

摘　　要：目的观察贞芪扶正颗粒联合替吉奥胶囊治疗晚期贲门癌效果。方法将52例患者随机均分为2组，单药组26例以单纯口服替吉奥胶囊方案治疗，联合用药组26例以贞芪服正颗粒联合替吉奥胶囊方案治疗。观察临床疗效、毒性作用及治疗前后细胞免疫功能改变情况。结果临床疗效单药组（46．2％）与联合用药组（50．0％）相比差异无统计学意义（χ^2=0．325，P〉0．05），但两组毒性作用：单药组恶心呕吐腹泻发生率（50．0％）与联合用药组（15．4％）相比差异统计学意义（χ^2=0．1490，P〈0．05），单药组白细胞减少发生率（26．9％）与联合用药组（11．5％）相比差异统计学意义（χ^2=2．000，P〈0．05），同时治疗前后细胞免疫功能改变情况联合组明显优于单药组（P〈0．05）。结论贞芪扶正颗粒联合替吉奥胶囊治疗晚期贲门癌疗效肯定，能有效减轻因化疗所致的不良反应，提高患者的耐受性，改善细胞免疫功能。Objective To study the clinical effect of Zhenqifuzheng granule combined with Tegafur gimeracil oteracil potassium capsule in treating advanced carcinoma of gastric cardia in aged patients. Methods 52 cases of aged patients with advanced carcinoma of gastric cardia were randomly divided into the observation group and the control group. The observation group was treated with zhenqi fuzheng granule combined with tegafur gimeracil oteracil potassium capsule, and the control group was given Tegafur gimeracil oteracil potassium capsule only. The curative effect,adverse reaction and cellular immune function were evaluated after two treatment cycles. Results There was no statistically significant difference in the objective efficacy rate between observation （46.2%） and control group （50.0%） （P〉0.05）. The rate of adverse reaction was higher in the control group than in observation group （P〈0.05）. The rate of gastrointestinal adverse reactions in the control group was 50.0%, but 15.4% in observation group. The rate of bone marrow suppression was 26.9% in control group, but 11.5% in observation group. The cellular immune function was better in observation group than in the control group （ P〈 0.05）. Conclusions Zhenqifuzheng granule can improve immune function and reduce toxic side effects when combined with Tegafur gimeracil oteracil potassim capsule in treating advanced carcinoma of gastric cardia in aged patients.

关 键 词：胃肿瘤 嘧啶类 扶正 

分 类 号：R735.2[医药卫生—肿瘤]