钆塞酸二钠增强MRI肝胆期信号与肝细胞肝癌分化程度的关系  

The Relationship Between Signal Intensity on Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI and The Degree of Differentiation of Hepatocelluar Carcinoma

作　　者：刘曦娇[1] 唐鹤菡[1] 张笑[2] 林丽丽[1] 刘洋洋[1] 黄子星[1] 陈国勇[1] 蔡磊[1] 宋彬[1] 

机构地区：[1]四川大学华西医院放射科,四川成都610041 [2]乐山市人民医院CT/MRI室,四川乐山614000

出　　处：《中国普外基础与临床杂志》2014年第12期1583-1586,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金面上项目资助(项目编号:81171338;81471658)~~

摘　　要：目的探索钆塞酸二钠(Gd-EOB-DTPA)增强MRI肝胆期信号与肝细胞肝癌(HCC)分化程度的关系。方法回顾性分析2011年11月至2014年2月期间笔者所在医院收治的48例HCC患者的Gd-EOB-DTPA增强MRI肝胆期图像,分别计算信号噪声比(SNR)、对比率(CR)、信号噪声比强化率(%EnhancementSNR)、对比率强化率(%EnhancementCR)、强化率(ER)和相对强化率(RER),比较不同分化程度HCC患者肝胆期各信号指标的差异。结果 48例患者中,分化程度为高分化6例,中分化24例,低分化18例;肝功能Child-Turcotte-Pugh(CTP)A级37例,B级11例。不管是在CTP A级患者中,还是在所有HCC患者中,高、中及低分化HCC的SNR、CR、%EnhancementSNR、%EnhancementCR、ER及RER比较差异均无统计学意义(P>0.05)。结论 Gd-EOB-DTPA增强MRI肝胆期信号指标预测HCC分化程度的价值有限。Objective To explore the relationship between the signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid （Gd-EOB-DTPA） -enhanced MRI and the degree of differentiation of hepatocelluar carcinoma （HCC）. Methods Forty-eight cases of HCC with Gd-EOB-DTPA-enhanced MRI images in our hospital were retrospectively included. The signal to noise ratio （SNR）, contrast ratio （CR）, enhancement ratio of signal to noise ratio （%EnhancementsNR） , enhancement ratio of the contrast ratio （%EnhancementcR）, enhancement ratio （ER）, and relative enhancement ratio （RER） were calculated, respectively. Then comparisons of these signal values among different differentiations of HCC were performed. Results Among the 48 cases ofHCC, there were 6 cases of well differentiated, 24 cases of moderately differentiated, and 18 cases of poorly differentiated. There were 37 cases of Child-Turcotte-Pugh （CTP） A classification and 11 cases of B classification, respectively. Neither in all cases nor in cases of CTP A classification, there was no statistically significant difference in SNR, CR, %EnhancementsNR, %EnhancementCR, ER, and RER among cases of different differentiation （P〉 0. 05）. Conclusion The signal intensity on hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI has limited value in predicting the degree of differentiation of HCC.

关 键 词：钆塞酸二钠 磁共振成像 肝细胞肝癌 分化程度 

分 类 号：R735.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]