GLUT1、VEGF、Ki67蛋白在血管瘤和血管畸形中的表达及其意义  

The expression and clinical significance of GLUT1,VEGF,Ki67 protein in hemangioma and vascular malformation

作　　者：周梅[1] 江仁兵[2] 白靖平[2] 张焕[1] 叶明[1] 

机构地区：[1]新疆医科大学附属肿瘤医院病理科,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院骨科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2014年第12期1577-1580,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81360282)

摘　　要：目的探讨葡萄糖转运蛋白(GLUTl)、血管内皮细胞生长因子(VEGF)和Ki67在血管瘤和血管畸形中的表达及其临床意义。方法收集2006-2010年新疆医科大学附属肿瘤医院病理科皮肤增殖期血管瘤标本20例和软组织血管畸形标本40例,采用免疫组化S-P法检测GLUT1、VEGF、Ki67蛋白在血管瘤和血管畸形中的表达。结果 GLUT1和Ki67在增殖期血管瘤组织中的阳性表达均较强,Ki67在血管畸形组织中仅见个别细胞表达,GLUT1在血管畸形组织中未见阳性表达,GLUTl和Ki67在血管瘤中的阳性表达率明显高于血管畸形,差异有统计学意义(P<0.05)。VEGF在增殖期血管瘤中的表达也高于血管畸形,差异有统计学意义(P<0.05)。结论 GLUT1、VEGF和Ki67在血管瘤中高表达,在血管畸形中低表达或不表达,可能有助于血管瘤和血管畸形的鉴别,其表达情况也为临床治疗血管病变提供了新思路。Objective To explore the expressions of glucose transporter （GLUTl）,vascular endothelial growth factor （VEGF）and Ki67 protein in hemangioma and vascular malformation.Methods 20 speci-mens of skin proliferative hemangioma and 40 specimens of vascular malformation of soft tissues from De-partment of Pathology of Tumor Hospital Affiliated to Xinjiang Medical University in 2006 - 2010 were collected to detect the expressions of GLUT1,VEGF,Ki67 protein by immunohistochemical method in hemangioma and vascular malformation.Results The expressions of GLUT1 and Ki67 protein were strongly positive in proliferation phase hemangioma; the expressions of Ki67 protein were only in individual cells in vascular malformation,with no positive expression of GLUT1 protein in vascular mal-formation.The positive expressions of GLUT1 and Ki67 protein in hemangioma were significantly higher than those in vascular malformation,and the difference was statistically significant （P 〈0.05）.The expres-sion of VEGF protein in hemangioma was also higher than that in vascular malformation and the difference was statistically significant （P 〈0.05）.Conclusion The expressions of GLUT1,VEGF and Ki67 protein are high in hemangioma,but low or absent in vascular malformation,which helps identify hemangioma and vascular malformation and provide new ideas for the treatment of hemangioma lesion.

关 键 词：血管瘤 血管畸形 葡萄糖转运蛋白-1 血管内皮生长因子 

分 类 号：R365[医药卫生—病理学]