天然虾青素对大鼠MCAO模型的保护作用研究  

Protective effect of natural astaxanthin on rat cerebral ischemia / reperfusion injury

作　　者：潘雷[1] 周莹[1] 刘路明[1] 万庆家[2] 孙承锋[1] 尹勇[1] 迟越[2] 

机构地区：[1]昆明医科大学第四附属医院康复医学科,云南昆明650021 [2]云南中医学院,云南昆明650500

出　　处：《中国民族民间医药》2014年第23期9-11,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：云南省科技计划项目(2010CD186);云南省教育厅科学研究基金项目(2010C083)

摘　　要：目的:探讨天然虾青素对大鼠脑缺血/再灌注损伤的保护作用及机制。方法:采用线栓法复制大鼠局灶性脑缺血/再灌注损伤(MCAO)模型,以神经学评分、脑梗塞体积、血清超氧化物歧化酶(SOD)、丙二醛(MDA)为评价指标,考察天然虾青素的脑保护作用。结果:天然虾青素能够明显改善模型动物的神经病学症状,缩小脑梗塞体积,升高血清SOD活性,降低血清MDA水平。结论:天然虾青素在防治大鼠脑缺血/再灌注损伤方面具有明显作用,其作用与抗氧化损伤有关。Objective To observe the effect of the natural astaxanthin on the rat model of cerebral ischemia/reperfusion injury and detect the mechanism of it. Methods The middle cerebral artery occlusion （MCAO） model was used. The neurological score, infarct volume, the content of SOD and MDA in the serum were evaluated. Results The results showed that the natural astaxanthin could sig- nificantly improve the neurological symptoms, reduce the infarct volume, increase the activity of SOD and decrease the content of MDA in serum. Conclusion The natural astaxanthin had a significant protective effect on rat cerebral ischemia/reperfusion injury. The mechanism may be related to antioxidant.

关 键 词：虾青素 脑缺血/再灌注 抗氧化 

分 类 号：R965.1[医药卫生—药理学]