不典型增生在结节性甲状腺肿及癌周组织中的意义  

Significance of Atypical Hyperplasia in Nodular Goiter and Surrounding Cancer Tissues

作　　者：刘楠楠[1] 于春艳[1] 董志恒[1] 刘玉和[1] 盖晓东[1] 

机构地区：[1]北华大学基础医学院,吉林吉林132013

出　　处：《北华大学学报（自然科学版）》2014年第6期756-758,共3页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(201215103)

摘　　要：目的探讨不典型增生在结节性甲状腺肿及癌周组织中的意义.方法选择208例结节性甲状腺肿及52例伴有癌周组织的甲状腺癌标本进行HE染色,光镜观察,并分析病变结构.结果结节性甲状腺肿伴有不典型增生病例为6.3%,其中轻-中度与重度不典型增生病例分别为5.3%和0.96%;癌周组织中伴有不典型增生病例为13.5%,其中轻-中度与重度不典型增生病例分别为7.7%和5.8%.结论不典型增生是甲状腺癌的癌前病变,对结节性甲状腺肿伴有不典型增生病例应密切随访,以防癌变.Objective To explore the significance of atypical hyperplasia in nodular goiter and surrounding cancer tissue. Method Specimens of 208 cases with nodular goiter and surrounding cancer tissue specimens of 52 cases with thyroid carcinoma were selected. The specimens were dyed with HE staining and examined with light microscope. Their pathological structures were analyzed. Results Cases of nodular goiter with atypical hyperplasia were 6. 3%,of which slight-middle cases and severe atypical hyperplasia were respectively 5. 3% and 0. 96%;Cases of surrounding cancer tissue with atypical hyperplasia were 13. 5%,of which slight-middle cases and severe atypical hyperplasia were respectively 7 . 7% and 5 . 8%. Conclusion Atypical hyperplasia is a precancerous lesion of thyroid carcinoma. Cases of nodular goiter with atypical hyperplasia should be closely followed up in order to avoid the cancer.

关 键 词：结节性甲状腺肿 不典型增生 癌周组织 

分 类 号：R361.2[医药卫生—病理学]