胃癌组织中HIF-1α、STAT3的表达变化及其与患者预后的关系  

Expression of hypoxia-inducible factor-1α and signal transducer and activator of transcription 3 and its association with prognosis of gastric cancer

作　　者：陈昌荣 徐桂芳[1] 周志华[2] 管文贤[1] 汪灏[1] 孙琦[1] 徐新运[1] 张伟杰[1] 

机构地区：[1]南京大学医学院附属鼓楼医院,南京210008 [2]解放军第101医院

出　　处：《山东医药》2014年第43期5-7,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81201909);江苏省南京市医学科技发展项目(QYK11166;YKK12072)

摘　　要：目的观察胃癌组织中缺氧诱导因子-1α(HIF-1α)、信号传导与转录活化因子3(STAT3)的表达变化及其与患者预后的关系。方法免疫组化染色法检测123例份胃癌根治术切除的胃癌组织和53例份正常胃黏膜组织中的HIF-1α和STAT3。结果胃癌组织中HIF-1α、STAT3的阳性表达率分别为64.2%(79/123)和62.6%(77/123),与正常胃黏膜组织的39.6%(21/53)和43.4%(23/53)相比,P均<0.05。HIF-1α及STAT3的阳性表达与胃癌病理分化程度、肿瘤浸润深度、有无淋巴结转移、TNM分期及有无血管侵袭有关(P均<0.05),HIF-1α、STAT3共同阳性表达率随胃癌TNM分期的升高而升高(r=0.377,P<0.05)。胃癌组织中HIF-1α与STAT3的表达呈正相关(r=0.335,P<0.05)。HIF-1α和STAT3阳性表达者术后5年生存率分别为21.9%和27.4%,阴性表达者分别为51.2%和41.5%,二者相比,P均<0.05。胃癌组织中HIF-1α阳性表达是影响胃癌患者预后的独立危险因素(RR=2.162,P<0.05)。结论胃癌组织中HIF-1α、STAT3的阳性表达率升高,二者的表达呈正相关,HIF-1α、STAT3阳性表达者的预后差,HIF-1α阳性表达和TNM分期对评估胃癌患者的预后有一定价值。Objective To investigate the relationship between expression of hypoxia-inducible factor-1α（HIF-1α） and signal transducer and activator of transcription 3（STAT3） in gastric cancer tissue and analyze their prognostic value .Methods The ex-pression of HIF-1αand STAT3 in 123 gastric cancer patients who underwent radical resection and 53 cases of control with normal gas-tric tissue were examined by immunohistochemistry.Results The positive protein expression rates of HIF-1αand STAT3 in the gas-tric cancer tissue were 64.2%（79/123） and 62.6%（77/123）, which were significantly higher than those in the normal tissue 39.6%（21/53） and 43.4%（23/53）（all P〈0.05）.The proteins expression of HIF-1αand STAT3 were in correlation with the degree of dif-ferentiation, TNM staging, lymph node metastasis, vessel invasion and invasion depth（P〈0.05）, and the co-expression rates of HIF-1αand STAT3 were correlated with the TNM stages（r=0.377, P〈0.05）.In gastric cancer tissue, the expression of HIF-1αwas positively correlated with the expression of STAT3 （r=0.335, P〈0.05）.The 5-year survival rate of patients with positive ex-pression of HIF-1αand STAT3 were 21.9%and 27.4%, which were significantly lower than those with negative expression（all P〈0.05）, whose 5-year survival rates were 51.2%and 41.5%.HIF-1αexpression were independent prognostic factors for gastric cancer （RR=2.162, P〈0.05）.Conclusions In gastric cancer tissue, the expressions of HIF-1αand STAT3 are elevated and positively correlated.Patients with positive expression of HIF-1αand STAT3, the prognosis are poor.Expression of HIF-1αand TNM staging are useful for predicting the prognosis of patients with gastric cancer .

关 键 词：胃肿瘤 胃癌 缺氧诱导因子-1Α 信号传导与转录活化因子3 

分 类 号：R735.2[医药卫生—肿瘤]