蛋白质高分子药物载体研究进展  

Advances in Protein-based Polymer Drug Carriers

作　　者：李榕[1] 何玉凤[1] 马琼[1] 王荣民[1] 

机构地区：[1]生态环境相关高分子材料教育部重点实验室甘肃省高分子材料重点实验室西北师范大学高分子研究所,兰州730070

出　　处：《化学通报》2014年第6期484-489,共6页Chemistry

基　　金：国家自然科学基金项目(21263024,21364012);长江学者和创新团队发展计划项目(IRT1177)资助

摘　　要：作为一类具有独特优势的生物高分子,蛋白质具有很好的生物相容性、生物可降解性、生物稳定性、极低的细胞毒性,且具有较高的载药性。在现有的多种药物载体中,基于动物蛋白的药物载体是最有潜力和值得关注的载药系统。常用于药物载体的动物蛋白中,使用较多的是白蛋白、胶原蛋白、乳清蛋白、角蛋白等。本文就几类重要的动物蛋白质载体的研究进展进行综述,并指出蛋白质高分子药物载体的发展方向。Acting as a kind of excellent biopolymer, protein shows good biocompatible, biodegradable, biostable, low cytotoxic and high drug loading property. Among the available drug carrier systems, protein-based carriers are promising candidates for efficient carrying drug, which has been paid attention in recent years. In this paper, some typical animal proteins, such as albumin, collagen, whey protein and keratin, are introduced. Then, preparation of protein-based polymer carriers and their application in drug delivery systems have also been reviewed. Finally, trend of development in animal protein-based polymer drug carriers has been prospected.

关 键 词：药物载体 动物蛋白 蛋白基高分子 生物高分子载体 控制释放 

分 类 号：TQ460.1[化学工程—制药化工]