KAI1及CD44V6在胃癌中的表达及意义  

Expression and Significance of KAI1 and CD44V6 in Gastric Carcinoma

作　　者：王武[1] 谢金标[1] 杨天宝[1] 卢辉山[2] 张捷[2] 

机构地区：[1]莆田学院附属医院,351100 [2]福建医科大学附属协和医院,350001

出　　处：《实用癌症杂志》2014年第5期498-500,521,共4页The Practical Journal of Cancer

摘　　要：目的研究KAI1和CD44V6在胃癌中的表达和意义,探讨它们之间的关系。方法采用免疫组化技术检测61例胃癌组织和20例癌旁正常胃组织中KAI1和CD44V6的表达情况。结果胃癌组织中KAI1蛋白的阳性率显著低于癌旁正常胃组织(P<0.05);胃癌组织中CD44V6蛋白的阳性率显著高于癌旁正常胃组织(P<0.05);KAI1、CD44V6的表达与胃癌的浆膜侵犯、临床分期、组织分化程度、淋巴结转移显著相关(P<0.05),而与年龄、性别无关(P>0.05)。KAI1与CD44V6在胃癌组织中的表达呈负相关(P<0.01)。结论 KAI1与CD44V6在胃癌的发生、发展和侵袭转移中起着相互抑制的作用,检测KAI1及CD44V6蛋白对于判断胃癌的生物学行为具有重要的价值。Objective To study the expression of KAI1 and CD44V6 in gastric carcinoma and its clinical significance , and to investigate their relationship .Methods SP immunohistochemistry was used to detect the expression of KAI 1 and CD44V6 protein in 61 cases of gastric carcinoma tissues and 20 cases of adjacent normal gastric tissues .Results The positive rate of KAI1 in gastric carcinoma tissues was significantly lower than that of the adjacent normal gastric tissues （P〈0.05） ,and the pos-itive rate of CD44V6 in gastric carcinoma tissues was significantly higher than that of the adjacent normal gastric tissues （ P〈0.05）.The expression of KAI1 and CD44V6 was associated with serosal invasion , the tumor stage ,grade of tumor differentia-tion,lymph node metastasis（P〈0.05） while not related with age, and sex（P〉0.05）.KAI1 expression was negatively correla-ted with CD44V6 expression（P〈0.01）.Conclusion KAI1 and CD44V6 protein restrains each other in the happening、devel-opment、invasion and metastasis of gastric carcinoma ,the detection of KAI1 and CD44V6 protein is of important value in evalua-ting biological behaviors of gastric carcinoma .

关 键 词：胃肿瘤 KAI1 CD44V6 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]