术前新辅助化疗对巨块型宫颈癌的疗效研究  

The Reasearch of Neoadjuvant Chemotherapy on Bulky Cervical Carcinoma

作　　者：汤巍巍[1] 于明新[1] 尉阳[2] 程召霞 

机构地区：[1]辽宁省肿瘤医院妇科,110042 [2]中国医科大学盛京医院妇产科,110042 [3]沈阳市妇婴医院妇产科,110015

出　　处：《实用癌症杂志》2014年第5期538-540,共3页The Practical Journal of Cancer

摘　　要：目的：探讨术前新辅助化疗对巨块型宫颈癌的临床疗效。方法选择巨块型宫颈癌患者28例，术前联合化疗2～3个周期，再行广泛性全子宫切除加盆腔淋巴结清扫。结果新辅助化疗后Ⅰb期患者临床有效率为100％；Ⅱa期患者为77．8％；Ⅱb期患者为71．4％。总有效率为85．7％。新辅助化疗后阴道出血、阴道排液、疼痛等症状改善明显，术后病理检查示病灶切除完全。1例Ⅰb期3年内复发；1例Ⅱa期2年内复发，2例Ⅲa期3年内复发；1例Ⅱb期1年内复发，2、3年内复发各2例。结论局部晚期巨块型宫颈癌术前新辅助化疗均能改善临床症状、缩小病灶体积，有助于手术顺利进行，改善患者预后。Objective To observe the clinical efficacy of neoadjuvant chemotherapy on bulky cervical carcinoma .Meth-ods 28 patients with bulky cervical carcinoma received 2 or 3 cycles of combined chemotherapy before extensive hysterectomy and pelvic lymph node dissection .Results The effective rate of stage Ⅰb patients was 100.0%,while in stage Ⅱa andⅡb pa-tients were 77.8%and 71.4%,respectively,total efficacy rate was 85.7%.The clinical symptoms improved significantly after neoadjuvant chemotherapy ,all surgical margins were negative .All cases were followed up ,1 case ofⅠb recurred in 3 years,1 case ofⅡa recurred in 2 years,2 cases of Ⅲa recurred in 3 years,1 case of Ⅱb recurred in 1 year.Conclusion The neoadjuvant chemotherapy on cervical cancer before surgery can alleviate clinical symptoms significantly ,reduce tumor size,contribute to the smooth progress of the operation ,and improve prognosis .

关 键 词：新辅助化疗 巨块型 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]