宁夏2198例男性不育患者的细胞遗传学分析  

Cytogenetic Analysis of 2198 Cases Male Infertility from Ningxia

作　　者：宋晓霞[1] 党洁[1,2] 焦海燕[1,2] 张玉玲[3] 钟慧军[1,2] 彭亮[3] 陆宏[1,2] 

机构地区：[1]宁夏医科大学教育部生育力保持教育部重点实验室,宁夏生殖与遗传重点实验室,银川750004 [2]宁夏医科大学基础医学院细胞生物学与医学遗传学教研室,银川750004 [3]宁夏医科大学实验中心,银川750004

出　　处：《宁夏医科大学学报》2014年第5期533-535,共3页Journal of Ningxia Medical University

基　　金：国家自然科学基金(30960154)

摘　　要：目的通过对宁夏2198例男性不育患者进行细胞遗传学分析,探讨染色体异常与男性不育之间的关系。方法外周血淋巴细胞培养,常规G显带进行染色体核型分析。结果 2198例男性不育患者中,异常核型232例,检出率10.56%。其中常染色体异常51例,占21.98%;性染色体异常61例(包括性反转1例),占26.29%;染色体多态性120例,占51.73%。结论染色体异常是导致男性不育的重要因素之一。对高危人群进行染色体检查,可为临床提供科学的诊断依据和治疗方案的选择。Objective To explore the relationship between male infertility and chromosomal abnormalities in Ningxia. Methods 2198 consultative patients were performed by peripheral blood lymphocytes culturing to make chromosome G- banding and to analyze the karyotype standard techniques. Results A total of 2198 patients of male infertility were detected and the detection rate was 10.56%. Among 232 abnormal karyo- types, 51 cases were euchromosome abnormalities , 61 cases were sex chlomosome abnormalities and 120 ea- ses were chromosome polymorphism. The rate of euchromosome abnormalities, sex chromosome abnormalities and chromosome polymorphism were 21.98%, 26.29% and 51.73% respectively. Conclusion Chromo- some abnormalities is a considerable reason for male infertility . Cytogeneties detection for high risk group can provide a scientific basis for clinical diagnosis and treatment.

关 键 词：男性不育 染色体异常 核型分析 

分 类 号：R698.2[医药卫生—泌尿科学]