事件相关电位检测结合学习障碍筛查量表对癫痫患儿认知功能的评估  

Event-related Potential Combined with Pupil Rating Scale Revised Screening to Evaluate Cognitive Function in Children with Epilepsy

作　　者：刘南平[1] 陈景云[1] 潘宗[1] 张晨[1] 董亮艳[1] 

机构地区：[1]宁夏医科大学总医院心脑血管病医院神经电生理室,银川750002

出　　处：《宁夏医科大学学报》2014年第8期865-867,共3页Journal of Ningxia Medical University

基　　金：宁夏医科大学"博士学位建设学科"开放课题

摘　　要：目的探讨事件相关电位检测结合学习障碍筛查量表对癫痫患儿认知功能评估的价值。方法采用脑电图(EEG)检查结合事件相关电位(ERP P300)检测及学习障碍筛查量表(PRS)测评对60例癫痫患儿(A组:病程>3年、发作次数>10次∕年,共39例;B组:病程<3年、发作次数<10次∕年,共21例);30例正常对照组儿童进行检测分析。结果 160例癫痫患儿脑电图异常53例(88.3%),其中癫痫样放电49例,占92.5%(49/53)。2癫痫组P300潜伏期较对照组延长(P<0.05);癫痫组学习障碍筛查量表总分、言语得分及非言语得分均低于对照组(P<0.05)。3A组患儿P300潜伏期长于B组(P<0.05),PRS量表测评得分均A组小于B组(P<0.05)结论癫痫儿童存在认知缺陷及学习障碍;P300检测结合PRS测评可作为客观评价指标。Objective To investigate the evaluation of event - related potentials combined with pupil rating scale revised screening for assessment of cognitive function in children with epilepsy. Methods 60 cases of children with epilepsy were evaluated with electroencephalogram （EEG） examination combined with event - related potentials （ERP P300） testing and Pupil Rating Scale Revised Screening （PRS） （ Group A： duration greater than three years,the number of episodes 〉 10 times/year, a total of 39 cases . Group B： duration of less than three years, the number of episodes of 〈 10 times/year, a total of 21 cases ）. Results ①53 cases showed abnormal EEG in 60 epileptic children （88.3%） ,which epileptiforrn discharges in 49 cases, account- ing for 92.5% （49/53） . ②Compared with the control group, P300 latency prolonged in epilepsy group （P 〈 0.05）. learning disabilities screening scale scores, verbal and non - werbal scores scores in epilepsy group were significantly lower than those in the control group （P 〈 0.05 ）. ③P300 latency in A group was longer than that in group B （ P 〈 0.05 ）. PRS Assessment Scale scores in group A were lower than that in group B （ P 〈 0.05 ）. Conclusion Cognitive defects and learning disabilities exist in children with epilepsy. P300 de- tection combined PRS Evaluation can be used as an objective evaluation index for cognitive function in epilepy children.

关 键 词：癫痫儿童 认知学习障碍 事件相关电位P300 学习障碍筛查量表 

分 类 号：R742.1[医药卫生—神经病学与精神病学]