胰腺癌与幽门螺杆菌感染相关性研究  

Correlation study of pancreatic cancer and Hp infection

作　　者：李庆东[1] 匡毅[2] 邓和军[1] 

机构地区：[1]重庆市肿瘤研究所肝胆外科,重庆400030 [2]重庆市肿瘤研究所腹部肿瘤外科,重庆400030

出　　处：《中华医院感染学杂志》2014年第23期5861-5863,共3页Chinese Journal of Nosocomiology

基　　金：重庆市科技计划基金资助项目(2008BB5029)

摘　　要：目的探讨胰腺癌与幽门螺杆菌(Hp)感染之间的关系,为临床胰腺癌防治提供参考。方法选取2012年8月-2013年8月医院收治的胰腺癌患者56例作为观察组,对其血清中的抗Hp-IgG、Hp-IgM和CagA-Hp-IgG进行测定,并与对照组60名体检健康人员的相关指标进行比较分析,数据采用SPSS16.0进行统计分析。结果 Hp感染率观察组为64.29%、对照组为46.67%,观察组显著高于对照组;CagA-Hp阳性率观察组为38.88%、对照组为21.53%,观察组高于对照组,两组比较差异有统计学意义(P<0.05);胰腺癌患者Hp感染与其吸烟史、慢性胰腺炎病史有关(P<0.05)。结论 Hp感染为胰腺癌危险因素之一,CagA-Hp阳性者胰腺癌危险更甚,加强对Hp感染的防治对胰腺癌的防治具有重要意义。OBJECTIVE To investigate the relationship between pancreatic cancer and Helicobacter pylori （Hp） infection and provide reference for clinical prevention and treatment of pancreatic cancer .METHODS Totally 56 patients with pancreatic cancer admitted to the hospital during Aug .2012 to Aug .2013 were selected as the obser‐vation group .Their serum anti Hp‐IgG ,Hp‐IgM and CagA‐Hp‐IgG were measured and compared with the relat‐ed indicators of the control group including 60 healthy subjects .RESULTS The Hp infection rate was 64 .29% in the observation group ,significantly higher than 46 .67% in the control group .The CagA‐Hp positive rate was 38 .88% in the observation group ,significantly higher than 21 .53% in the control group （P〈0 .05） .Hp infection in patients with pancreatic cancer was associated with their smoking history and history of chronic pancreatitis （P〈0 .05） .CONCLUSION Hp infection is one of the risk factors for pancreatic cancer ,and patients with positive CagA‐Hp have higher risk for pancreatic cancer .Strengthening the prevention and treatment of Hp infection is of great importance for prevention and treatment of pancreatic cancer .

关 键 词：胰腺癌 幽门螺杆菌 感染 相关性 

分 类 号：R735.9[医药卫生—肿瘤]