CCNG2在前列腺癌中的表达及其临床意义  

Expression of CCNG2 in Prostate Cancer and Its Significance

作　　者：孙国贵[1] 崔大为[2] 程云杰[3] 景绍武[3] 刘青[3] 杨从容[3] 

机构地区：[1]唐山市人民医院,河北唐山063000 [2]唐山市工人医院,河北唐山063000 [3]河北医科大学第四医院,河北石家庄050017

出　　处：《肿瘤学杂志》2014年第12期1018-1021,共4页Journal of Chinese Oncology

摘　　要：[目的]探讨细胞周期蛋白G2(CCNG2)在前列腺癌中的表达及意义。[方法]采用免疫组织化学方法、Western blot检测85例前列腺癌组织及距其癌组织边缘2cm以上镜下未见癌浸润的正常组织中CCNG2蛋白的表达情况。[结果]免疫组织化学结果表明,CCNG2蛋白在前列腺癌组织及正常前列腺组织中的表达阳性率分别为31.8%、96.5%,差异有统计学意义(P<0.05)。Western blot结果表明,CCNG2蛋白在前列腺癌组织的相对表达量较正常前列腺组织的相对表达量明显降低,差异具有统计学意义(P<0.05)。CCNG2蛋白表达与前列腺癌患者年龄、肿瘤大小、PSA水平无关(P>0.05);而与Gleason score、淋巴结转移以及肿瘤临床分期有关(P<0.05)。[结论]前列腺癌组织中CCNG2蛋白表达明显降低,且与前列腺癌Gleason score、淋巴结转移、临床分期有关。[Purposel To investigate the expression of Cyclin G2 （CCNG2） in prostate carcinoma and its clinical significance. [Methods] Immunohistochemistry and Western blot were used to detect CCNG2 protein expression in 85 cases of prostate cancer and ≥2cm cancer adjacent nor- mal tissues. [ Results] Immunohistochemistry：the level of CCNG2 protein expression was signifi- cantly lower in prostate cancer tissues than that in normal tissues（P〈0.05）. Western blot ：the rela- tive amount of CCNG2 protein in prostate cancer tissues was significantly lower than that in nor- mal tissues （P〈0.05）. The level of CCNG2 protein expression did not correlate with age, PSA con- tention and tumor size （P〉0.05）, but it correlated with lymph node metastasis,clinic stage and Gleason score（F〈0.05）. [Conclusion] Expression of CCNG2 downregulates in prostate cancer tis- sues and significantly correlates with lymph node metastasis, clinic stage and Gleason score. It suggests that CCNG2 may play an important role as a negative regulator to prostate cancer.

关 键 词：CCNG2 前列腺肿瘤 预后 肿瘤转移 

分 类 号：R737.25[医药卫生—肿瘤]