酪蛋白磷酸肽和维生素C联用对大鼠骨骼的影响  

A study on the effect of casein phosphopeptides and vitamin C combined on the rat bone

作　　者：刘忠华[1] 刘文杰[1] 张燕[1] 彭学莲[1] 

机构地区：[1]山东省疾病预防控制中心,山东济南250014

出　　处：《中国食品卫生杂志》2014年第6期554-557,共4页Chinese Journal of Food Hygiene

摘　　要：目的探讨酪蛋白磷酸肽和维生素C联合应用对大鼠骨密度的影响。方法将Wistar雄性大鼠按体重随机分为5组,分别设立0.3、0.6、1.8 g/kg BW三个剂量组及碳酸钙对照组和低钙对照组。各组均饲喂低钙基础饲料,剂量组灌胃强化了酪蛋白磷酸肽和维生素C的高效补钙胶囊样品1次/d;碳酸钙对照组灌胃522.5 mg/kg BW碳酸钙(含钙量与1.8 g/kg BW剂量组相同)1次/d;低钙对照组以等体积的去离子水灌胃。连续给予3个月后测试增加骨密度等各项指标。结果经口给予大鼠不同剂量的高效补钙胶囊,1.8 g/kg BW剂量组能明显提高大鼠的骨钙含量,增加股骨中点骨密度;0.6、1.8 g/kg BW剂量组能增加股骨远心端骨密度;且各组股骨重量不低于碳酸钙对照组。结论酪蛋白磷酸肽和维生素C联合应用可有效增加大鼠的骨密度。Objective To investigate the influence of casein phosphopeptides and vitamin C combined on the bone density of rats. Methods Wistar male rats were randomly divided into 5 groups by body weight（ three experimental groups and two control groups）. Three experimental groups were low,medium and high dose groups with the dosage of 5,10,30 times of human recommended amount respectively. All experimental groups were administered by gavage a low calcium foundation feed,and the efficient calcium capsule was administered once a day which contain casein phosphopeptides and vitamin C. Daily calcium carbonate consumption（ as Ca） of calcium carbonate control group was the same as high dose group,and low calcium control group were administered an equal volume of deionized water by gavage. Bone density and other indicators were detected after three months. Results High dose of casein phosphopeptides and vitamin C could significantly increase the rat bone calcium content and femur midpoint of bone density,the high and medium dose could increase the femur distal end bone density,and all experimental groups＇ femur weight were no less than the calcium carbonate control group. Conclusion The casein phosphopeptides and vitamin C combined could effectively increase bone mineral density

关 键 词：钙 碳酸钙 酪蛋白磷酸肽 维生素C 骨密度 补钙 强化营养素 

分 类 号：R580[医药卫生—内分泌]