结直肠癌患者围手术期血小板和血小板/淋巴细胞比值变化及其与预后的关系  

Correlation between perioperative changes in platelet count and platelet-lymphocyte ratio with prognosis of colorectal cancer

作　　者：蔡东焱[1] 吴小红[1] 洪婷婷[1] 张颖[1] 茆勇[1] 华东[1] 

机构地区：[1]江南大学附属医院无锡市第四人民医院肿瘤内科,无锡214062

出　　处：《中华实验外科杂志》2014年第12期2876-2878,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（81201600）;江苏省自然科学基金资助项目（BK2012538）

摘　　要：目的 观察手术前后血小板计数（PLT）与血小板/淋巴细胞比值（PLR）变化及其与结直肠癌预后的关系.方法 分析我院260例结直肠癌根治术患者,根据术前PLT和PLR值中位数（分别为216×10^9/L和138）以及手术前后的变化进行分组,采用单因素分析和Cox回归模型进行生存分析.结果 单因素分析显示术前PLR＜ 138组的生存明显优于对照组（P＜0.05）,而在Ⅲ期患者中术前PLT ＜216×10^9/L或PLR＜ 138者的生存均明显优于对照组（P＜0.05）;多因素分析显示术前PLR≥138是结直肠癌的独立危险因素[相对危险度（RR）：0.526;95％可信区间（CI）：0.324 ～0.854;P＜0.01].结论 术前PLT和PLR可以评估结直肠癌患者的预后,对Ⅲ期患者的预测价值更高.Objective To observe the change of peroperative period platelet （PLT） and plateletlymphocyte ratio （PLR） in colorectal cancer patients and their relationship with prognosis.Methods The clinical data of 260 patients with operable colorectal cancer were analyzed.The patients were grouped according to PLT and PLR median preoperative values （216 × 10^9/L and 138 respectively） and peroperative period changes.The overall survival rate was analyzed by univariate analysis and Cox regression model.Results Univariate analysis showed the overall survival rate of low preoperative PLR group （〈 138） was higher than high group （P 〈 0.05）.In patients with stage Ⅲ,the overall survival rate of low preoperative PLT or PLR group was significantly high than high group respectively （P 〈 0.05）.In Cox regression model,a high preoperative PLR was identified as an independent risk factor for poorer prognosis in patients with colorectal cancer [relative risk （RR）：0.526 ; 95% confidence interval （CI）：0.324-0.854 ; P 〈 0.01].Conclusion Preoperative PLT and PLR can be used clinically to assess the prognosis of colorectal cancer.The higher predictive value is found in patients with stage Ⅲ.

关 键 词：结直肠癌 血小板计数 预后 

分 类 号：R735.34[医药卫生—肿瘤]