生长抑素在胃肠道肿瘤所致恶性肠梗阻非手术治疗中的疗效观察  

Curative effect observation of somatostatin in the non-surgical treatment of malignant bowel obstruction caused by gastroenteric tumor

作　　者：殷华芳[1] 王琼[1] 袁明[1] 吴丹[1] 王南瑶[1] 费燕华[1] 刘涛[1] 孙霞[1] 

机构地区：[1]东南大学附属江阴市人民医院肿瘤中心,214400

出　　处：《中国实用医药》2014年第31期12-13,共2页China Practical Medicine

摘　　要：目的：观察生长抑素在无法行手术治疗的恶性肠梗阻治疗中的临床疗效。方法60例恶性肠梗阻患者,随机分为常规治疗组（对照组）28例和生长抑素组（治疗组）32例,治疗组给予常规治疗加用生长抑素（6 mg/d持续静脉泵入）3~12 d。比较两组的近期临床疗效。结果治疗组临床症状较对照组明显改善,腹痛腹胀缓解率分别为81.25%、57.14%,差异有统计学意义（P〈0.05）；肛门恢复排便排气比率分别为71.88%、53.57%,差异有统计学意义（P〈0.05）,且治疗组恢复肛门排气时间（4.5±1.5）d,明显早于对照组（6.8±2.1）d（P〈0.05）；治疗组胃肠引流量明显少于对照组,分别为（256±152）ml/d、（489±198）ml/d,差异有统计学意义（P〈0.01）；腹部平片显示肠管积气积液减少消失,治疗组（84.38%）明显优于对照组（67.86%）（P〈0.05）；生活质量明显改善, KPS评分分别为（58±10）分、（41±9）分,两组比较差异有统计学意义（P〈0.01）。结论在常规治疗基础上联合生长抑素治疗恶性肠梗阻,能显著改善患者临床症状,提高生活质量。Objective To observe the curative effect of somatostatin in the non-surgical treatment of malignant bowel obstruction （MBO）. Methods A total of 60 cases with MBO were randomly divided into conventional therapy group （control group, n=28） and somatostatin group （treatment group, n=32）. The treatment group received conventional therapy combined with somatostatin （6 mg/d through continuous intravenous pumping） for 3~12 d. The short-term curative effects of the two groups were compared. Results The clinical symptom of the treatment group was improved, compared with the control group. The remission rates of abdominal pain and distention in the two groups were 81.25%and 57.14%, and the difference was statistically significant （P〈0.05）. The rates of defecation and exhaust recovery in the two groups were 71.88% and 53.57%, and the difference was statistically significant （P〈0.05）. The exhaust recovery time of the treatment group was （4.5±1.5） d, which was obviously shorter than （6.8±2.1） d of the control group （P〈0.05）. The gastrointestinal drainage volume of the treatment group as （256±152） ml/d was remarkably less than （489±198） ml/d of the control group, and the difference had statistical significance （P〈0.01）. The plain abdominal radiograph showed the disappearance of pneumatosis and hydrops in intestinal canal, and the effect in the treatment group （84.38%） was obviously better than that of the control group （67.86%） （P〈0.05）. The life quality of patients was improved, and the KPS scores of the two groups were （58±10） points and （41±9） points. The difference between the two group was statistically significant （P〈0.01）. Conclusion Somatostatin combined with conventional therapy is effective in the treatment of MBO. It can remarkably improve the symptoms of MBO and enhance the life quality of patients.

关 键 词：生长抑素 恶性肠梗阻 疗效 

分 类 号：R735[医药卫生—肿瘤]