参松养心胶囊辅治失眠症患者的临床观察  

Clinical study of Shensongyangxin capsule in treatment of insomnia

作　　者：沈鑫[1] 沈洪涛[2] 李军荣[1] 李圣华[1] 王华梅[1] 陈靖[1] 

机构地区：[1]南京医科大学附属江宁医院神经内科,210000 [2]南京医科大学附属江宁医院药剂科,210000

出　　处：《疑难病杂志》2014年第11期1165-1167,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的：观察参松养心胶囊辅治失眠症的临床疗效。方法将72例失眠症患者随机分为治疗组和对照组，各36例。2组患者均给予心理治疗和行为干预，在此基础上治疗组加服参松养心胶囊每次4粒，每天3次，疗程4周；早期辅以艾司唑仑每晚1 mg，疗程1周。对照组加服艾司唑仑每晚1 mg，疗程4周。观察治疗前后匹兹堡睡眠质量指数量表（ PSQI）变化及临床疗效，并记录药物不良反应。结果2组治疗后PSQI总分均有改善，差异均有统计学意义（ P ＜0．05），且治疗组优于对照组（ P ＜0．05）。治疗前和治疗后差值比较，治疗组在睡眠质量、入睡时间、睡眠时间、睡眠效率、催眠药物，日间功能改善方面优于对照组，差异有统计学意义（ P ＜0．05），而睡眠障碍评分无显著差异（ P ＞0．05）。疗程结束后治疗组总有效率为8．7％，高于照组的6．8％（χ2=0．130， P ＜0．05）；治疗组不良反应发生率为5．％，对照组为3．2％，2组比较差异有统计学意义（χ2＝1．72， P ＜0．01）。结论参松养心胶囊辅治失眠症安全而有效。Objective To observe the therapeutic effect of Shensongyangxin capsule in the treatment of insomnia. Methods Seventy-two cases of insomnia were randomly divided into treatment group and control group , 36 cases in each grou.2 groups of patients were given psychological therapy and behavior intervention , on the basis of this therapy , treatment group were treated with Shensongyangxin capsule with 4 capsules each time, 3 times a day, for 4 weeks;early time combined with estazolam every night , 1 mg, 1 week course of treatment.Control group took estazolam every night , 1 mg, 4 week course of treatment.The Pittsburgh sleep quality index （ PSQI ） changes and clinical curative effect , and the adverse drug reaction were observed before and after treatment.Results The total score of PSQI were improved in both groups after treatment , the difference was statistically significant （ P 〈0.05）, and the treatment group better than in control group （ P 〈0.05.Com-pared the difference between before and after treatment , the treatment group’s sleep quality, sleep time, sleep time, sleep ef-ficiency , hypnotic medicaments , daytime function were better than the control group , the difference was statistically significant （ P 〈0.05）, but there was no significant difference of the sleep disorder score （ P〉0.05.After treatment, the total effec-tive rate of treatment group was 8.7%,higher than 6.8%in the control group （χ2 =0.130, P 〈0.05）;treatment group’s incidence rate of adverse reaction was .7%, and control group was 3.2%, there was significant difference between the 2 groups （χ2 =1.72, P 〈0.01.Conclusion It demonstrated that the Shensongyangxin capsule in treatment of insomnia was safety and effective.

关 键 词：失眠症 参松养心胶囊 艾司唑仑 

分 类 号：R740[医药卫生—神经病学与精神病学]