射频消融术治疗晚期胰腺癌的中远期疗效分析  

Clinical analysis of radio-frequency ablation in the treatment of advanced pancreatic cancer

作　　者：金鑫[1] 吕少诚[2] 刘飞德[3] 傅庭焕[3] 裴利娟[3] 史宪杰[2] 

机构地区：[1] 中国人民解放军总医院第一附属(304)医院肝胆外科,北京100037 [2] 中国人民解放军总医院肝胆外科,北京100853 [3] 中国人民解放军总医院第一附属(304)医院普外科,北京100037

出　　处：《国际外科学杂志》2014年第10期677-679,F0003,共4页International Journal of Surgery

摘　　要：目的 探讨射频消融术在晚期胰腺癌患者治疗中的效果及中远期随访情况.方法 回顾性分析304医院2008年1月-2012年12月行射频消融术治疗晚期胰腺癌28例患者的围手术期临床资料,并将该组资料与同期行姑息性手术治疗的140例晚期胰腺癌患者的临床资料进行对比分析,并对两组患者术后中远期的随访情况进行对比分析.结果 28例行射频消融术的晚期胰腺癌患者,肿瘤的平均最大直径为（4.8±1.6） cm,术中平均射频消融时间为（17.7±4.3） min,术后无胰瘘患者,无围手术期死亡患者,围手术期疼痛缓解率为88.9％.23例患者获得随访,随访率为82.1％,其1个月、6个月、1年的生存率分别为95.7％、65.2％、38.2％,平均生存时间为（14.6±2.2）个月,优于同期行姑息性手术治疗的晚期胰腺癌患者（97.4％、45.3％、19.1％,P=0.0306）.结论 对于不能行根治性切除的晚期胰腺癌患者,射频消融术是一种有效的治疗手段,能相对延长患者的生存时间.Objective To explore the clinical effect of radio-frequency ablation in the treatment of advanced pancreatic cancer.Methods Retrospectively analyzed the clinical data of 28 cases of radio-frequency ablation in the treatment of advanced pancreatic cance between January 2008 and December 2012 in 304 hospital.And choosed made 140 cases patients who only underwent the conservative treatment as the control group at the same period.Then compared the data of two groups patients.Results The mean tumor diameter was （4.8 ± 1.6） cm.The average radio-frequency time was （17.7 ± 4.3） minutes.There was no patient occurred of pancreatic fistula or postoperative bleeding,and no patient dead.Peri-operation pain relief rate was 88.9%.Twenty-three patients were followed up,and the follow up rate was 82.1%.The patients＆#39; survival rate who underwent radio-frequency ablation of 1 month,6 months and 1 year were 95.7%,65.2% and 38.2%.The average survival time was （14.6 ± 2.2） months.And the data was significantly higher than that of the control group patients （97.4%,45.3%,19.1%,P =0.0306）.Conclusions The radio-frequency ablation was one of an effective treatment method for the advanced pancreatic cancer patients.It can prolong the survival time of pancreatic cancer patients and alleviate the patient＆#39;s pain.

关 键 词：胰腺肿瘤 导管消融术 随访研究 回顾性研究 

分 类 号：R735.9[医药卫生—肿瘤]