EDI-OCT对中心性浆液性脉络膜视网膜病变脉络膜厚度的研究  

Assessment of choroidal thickness of central serous chorioretinopathy by optical coherence tomography with enhanced depth imaging

作　　者：杭荟[1] 王秀英[1] 刘庆淮[1] 

机构地区：[1]南京医科大学第一附属医院眼科,中国江苏省南京市210029

出　　处：《国际眼科杂志》2015年第1期104-107,共4页International Eye Science

基　　金：江苏高校优势学科建设工程资助项目(No.JX10231801)~~

摘　　要：目的:评价利用OCT加强深度扫描模式测量中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)脉络膜厚度的意义。方法:采用回顾性病例对照研究。纳入经临床确诊的CSC患者65例65眼和年龄、性别、屈光度相匹配的正常对照组50例50眼。使用光学相干断层扫描的加强深度扫描模式(coherence tomography with enhanced depth imaging,OCT-EDI)分别测量65例患者的患眼和对侧眼,以及50例50眼正常对照者的黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)。其中65例患者中有40例自愈,14例行光动力学(photodynamic therapy,PDT)治疗,11例行氩激光(laser photocoagulation,LP)治疗,分别测量3mo后的SFCT,与前次的比较进行统计学分析。结果:CSC患者65例的患眼和对侧眼,以及50例50眼正常对照组的SFCT测量结果分别为436.23±89.50,389.45±101.03,329.36±95.87μm。患眼和对侧眼SFCT分别与正常对照组比较,显著增加(P=0.008,P=0.013)。患眼的SFCT与对侧眼比较也有统计学差异(P=0.021)。PDT治疗后SFCT显著性降低(P=0.032),LP治疗后和自愈者SFCT水平较前降低,但未显示出统计学差异(P=0.057,0.076)。结论:OCT-EDI是观察CSC脉络膜形态的有效方法,CSC患者SFCT较对侧眼和正常对照组明显增高。AIM： To evaluate the meaning of using optical coherence tomography with enhanced depth imaging（ OCT- EDI） to measure choroidal thickness of central serous retinopathy（ CSC）.METHODS： With the retrospective case control study,65 patients（ 65 eyes） with CSC and 50 healthy controls（ 50eyes） with age, gender and diopter- matched were recruited in this study. OCT- EDI were used to measure the subfoveal choroidal thickness（ SFCT） in CSC eyes,the fellow eyes and also the control eyes. Of which 40 of the 65 CSC patients self- cured,14 of them were treated with photodynamic therapy（ PDT）,the left 11 accepted the laser photocoagulation（ LP）. SFCT were measured3 mo after that. Compared with the previous data,the statistical analysis was carried out.RESULTS： The SFCT value of 65 CSC eyes,65 fellow eyes and 50 control eyes were 436. 23 ± 89. 50,389. 45 ±101. 03 and 329. 36 ± 95. 87μ m,respectively. The SFCT of suffer and fellow eyes increased significantly compared to the control eyes（ P = 0. 008 and 0. 013,respectively）.There was also significant difference in SFCT between theCSC eyes and the fellow eyes（ P = 0. 021）. The SFCT were significantly decreased after PDT（ P = 0. 032）,but with no significant changes after LP or self- cured（ P = 0. 057 and0. 076,respectively）.CONCLUSION： OCT- EDI is a useful method to assess the choroidal topographic changes of CSC. The SFCT are significantly increased in the CSC eyes compared with that in the fellow eyes and the control eyes.

关 键 词：中心性浆液性脉络膜视网膜病变 脉络膜 光学相干断层摄影术 

分 类 号：R774.1[医药卫生—眼科]