Synthesis and Biological Activity of 6-methyl-4-hydroxy-2-pyrone Derivatives  

作　　者：Chi Jianguo Kong Xue Gao Yongchao Huang Yujie 

机构地区：[1]Key Laboratory of Applied Microbiology of Shandong Province /Institute of Biology,Shandong Academy of Sciences

出　　处：《Plant Diseases and Pests》2014年第4期43-45,共3页植物病虫害研究（英文版）

基　　金：Supported by Research Award Fund for Outstanding Young Scientists in Shandong Province(BS2011NY015);Science and Technology Development Plan of Shandong Province(2011GNC11101);"Twelfth Five-Year"Key Technology R&D Program(2011BAE06B004-11)

摘　　要：With maleic acid as the raw material, 6-methyl-4-hydroxy-2-pyrone, 6-methyl-4-alkoxy-2-pyrone and 6-methyl-4-hydroxy-3-acyl-2-pyrone derivatives were obtained via loop closing, O-alkylation and acylation reaction, and antifungal activity was also tested. Structure of products was characterized by 1H NMR and MS, and preliminary biological activity tests showed that some of this series of compounds had good inhibitory activity against Rhizoctonia solani and Fusarium mo- niliforme Sheld.With maleic acid as the raw material, 6-methyl-4-hydroxy-2-pyrone, 6-methyl-4-alkoxy-2-pyrone and 6-methyl-4-hydroxy-3-acyl-2-pyrone derivatives were obtained via loop closing, O-alkylation and acylation reaction, and antifungal activity was also tested. Structure of products was characterized by 1H NMR and MS, and preliminary biological activity tests showed that some of this series of compounds had good inhibitory activity against Rhizoctonia solani and Fusarium mo- niliforme Sheld.

关 键 词：PYRONE SYNTHESIS Antifungal activity 

分 类 号：O621.3[理学—有机化学] TQ460.1[理学—化学]