中枢神经细胞瘤临床病理分析  

Clinicopathological Analysis of Central Neurocytoma

作　　者：李峰[1,2] 陈佳菁[3] 郭国栋[1,2] 陈小岩[1,2] 

机构地区：[1]福建医科大学省立临床医学院 [2]福建省立医院,福建福州350001 [3]中国人民解放军第180医院

出　　处：《中外医学研究》2014年第30期42-44,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的：探讨中枢神经细胞瘤（CNC）的临床病理特点、免疫表型及鉴别诊断,提高对此瘤的认识,避免误诊。方法：分析10例CNC的临床表现、影像学、组织学和免疫表型特点。结果：10例CNC中男性5例,女性5例,年龄9-45岁,中位年龄27.5岁。所有肿瘤均位于脑室系统内。镜下,肿瘤由形态一致的小圆形细胞组成,胞质透明,有核周空晕,呈菊形团状或蜂窝状排列,可见特征性的无核神经元纤维基质岛（神经毡）。免疫组化示10例中枢神经细胞瘤NeuN、Syn（＋）,9例NSE（＋）,1例GFAP灶性（＋）,NF、CgA（-）,Ki-67均〈2%。CNC首选手术切除。10例病例随访未见复发。结论：中枢神经细胞瘤是一种伴神经元分化的罕见肿瘤,肿瘤全切术是治疗首选,总体预后良好。免疫组化有助于CNC的诊断及鉴别诊断。Objective：To study the clinicopathological features,immunophenotype and differential diagnoses of central neurocytoma（CNC） so as to further realize the tumor and avoid misdiagnosis.Method：Clinical manifestations,radiological,histological characteristics and immunophenotype were analyzed in 10 cases of CNC.Result：5 male and 5 female patients,with ages ranging from 9 to 45 years（mean age 27.5 years）,and all tumors were located in the ventricular system.Histologically,the tumor were composed of small uniform round cells.These tumor cells with clear cytoplasm and perinuclear halo were arranged in rosettes pattern and honeycomb pattern.The most dominant feature of CNC was the cell-free island of neuropil matrix.Immunohistochemically,10 cases were positive for NeuN and Syn,9 cases were positive for NSE,1 case was partly positive for GFAP,10 cases were negative for NF and CgA.The positive index of Ki-67 was very low in all cases,with less than 2% of the nuclei labeled.Surgical resection was the primary therapy of CNC.No recurrence were seen in the 10 patients followed-up.Conclusion：CNC is a rare tumor with neuronal differentiation.Surgical resection is the primary therapy,CNC has a benign prognosis. in general.Immunohistochemistry is very important for the diagnosis and differential diagnoses of CNC.

关 键 词：中枢神经细胞瘤 免疫组化 临床病理 鉴别诊断 

分 类 号：R739.4[医药卫生—肿瘤]