第二代与第三代二膦酸盐对正畸源性牙移动及牙根吸收的影响  

Effects of the second and third generation of bisphosphonates on orthodontic root resorption and tooth movement

作　　者：张体勇 王旭霞[2] 王胜林[3] 赵姝亚[2] 张君[2] 

机构地区：[1]枣庄市立第四医院,277500 [2]山东大学口腔医学院 [3]淄博市中心医院

出　　处：《山东医药》2014年第46期11-13,共3页Shandong Medical Journal

基　　金：山东省科学技术发展计划项目(2009GG20002042);济南市科技局科技攻关项目(2010GG01070)

摘　　要：目的探讨第二代与第三代二膦酸盐对大鼠牙齿正畸过程中移动距离和牙根吸收的影响。方法 96只正畸牙齿大鼠模型随机分为二代组与三代组各48只;分别于上颌左侧第一磨牙近中腭侧黏骨膜下注射50μL帕米膦酸钠、伊班膦酸钠,每3天1次。正畸加力第3、7、14 d时每组分别处死16只大鼠,随机选择其中8只测定牙齿移动距离并制作牙周组织学切片测定牙根吸收指数,另外8只采用扫描电镜观察牙根吸收情况。结果第3、7、14 d,两组牙齿移动距离均逐渐增加,但两者之间无显著差异;二代组牙根吸收指数在第3、7、14 d比三代组相对较大,但两者间的差异无统计学意义。结论帕米膦酸钠与伊班膦酸钠减缓正畸牙齿移动和减轻牙根吸收的作用相当。Objective To compare the effects of pamidronate and ibandronate on orthodontic tooth movement and orthodontic root resorption .Methods A total of 96 female, 6-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established .The rats were randomly divided into two groups , which were the pamidronate group and the ibandronate group with 48 rats in each group.Pamidronate（50μL） and ibandronate（50μL） were injected on the sub-periosteum area adjacent of the first permanent molars every 3 days during the experiment .The rats were executed in batch on the 3, 7 and 14 day during the orthodontic treatment .Eight of them were chosen for histology observation of periodontium and measuring the distances of the tooth movement .The remaining 8 were used for SEM observation of root resorption .Rsesults There is no significant differences between the pamidronate group and the ibandronate group on the movement distance of the first molar .And no significance was discovered between the pamidronate group and the ibandronate group on the root resorption lacunae .Conclusions Both pamidronate and ibandronate can inhibit orthodontic tooth movement and inhibits orthodontic root resorption .

关 键 词：帕米膦酸钠 伊班膦酸钠 正畸牙移动 牙根吸收 

分 类 号：R783.3[医药卫生—口腔医学]