带式真空干燥技术在连花清瘟胶囊生产中的应用  

Application of belt vacuum drying technology on production of Lianhua Qingwen capsule

作　　者：王玉峰[1] 王华[1] 李松[1] 李向军[1] 范文成[1] 刘敏彦[1] 

机构地区：[1]石家庄以岭药业股份有限公司,河北050035

出　　处：《北京中医药大学学报》2014年第11期789-792,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金："重大新药创制"国家科技重大专项(2011ZX09201-201-27)

摘　　要：目的利用多指标研究带式真空干燥技术在连花清瘟胶囊干燥工艺中的应用。方法根据带式真空干燥机的工作原理,以出粉率、休止角、堆密度、吸湿百分率以及有效成分连翘酯苷A和绿原酸的含量为考察指标,对带式真空干燥与原工艺喷雾干燥2种干燥工艺进行比较。结果真空带式干燥可有效的改善连花清瘟胶囊易吸潮、结块的问题,且不影响连翘酯苷A和绿原酸的含量。结论真空带式干燥工艺适合于连花清瘟胶囊产业化生产,值得在中药工业生产中推广应用。Objective In comparation with spray drying technology, to study belt vacuum drying technology on production of Lianhua Qingwen capsule. Methods According to the operating principle of pharmaceutical belt vacuum dryer, altogher six specifications were measured, including flour yield, angle of repose, bulk density, percentage of moisture absorption and the active ingredient contents of forsythiaside A and chlorogenic acid; all those were investigated in spray drying technology parallel. Results The belt drying vacuum technology solved effectively moisture absorption and agglomeration of Lianhua Qingwen capsule, without loss of the active ingredient contents of forsythiaside A and chlorogenic acid. Conclusion Belt vacuum drying technology was suitable for the drying process of industrialization of Lianhua Qingwen capsule.

关 键 词：连花清瘟胶囊 带式真空干燥 喷雾干燥 生产应用 

分 类 号：R283.6[医药卫生—中药学]