紫杉醇/奈达铂与氟尿嘧啶/顺铂周剂量同步放化疗对中晚期食管癌近期疗效对照研究  

Short-term effect analysis of Paclitaxel / Nedaplatin and Cisplatin /5-Fu in weekly concurrent chemoradiotherapy for advanced esophageal cancer

作　　者：邰国梅[1] 蔡晶[1] 成国建[1] 赵季忠[1] 

机构地区：[1]江苏省南通市肿瘤医院放疗科,南通226361

出　　处：《临床医学》2014年第12期6-8,共3页Clinical Medicine

摘　　要：目的比较紫杉醇/奈达铂方案(TN)与5-氟尿嘧啶/顺铂(PF方案)在中晚期食管癌周剂量同期放化疗中近期疗效。方法选择72例中晚期食管癌患者,配对分为TN方案同期放化疗组和PF方案同期放化疗组,分别于放疗结束时和放疗后3个月观察两组近期疗效。结果 1 TN组和PF组放疗结束时有效率分别为88.89%和86.11%(P=0.722),两组放疗后3个月的有效率分别为91.67%和69.44%(P=0.017)。TN组和PF组放疗结束时局部病灶完全缓解率分别为38.88%和25.00%(P=0.206),两组放疗后3个月局部病灶完全缓解率分别为69.44%和44.44%(P=0.032)。2TN组外周神经炎、白细胞减少反应稍高,而对患者生活质量影响较低,且疲劳、恶心恶吐、食欲减退及腹泻、便秘等症状较PF组发生率低。结论 TN方案同期放化疗与PF方案同期放化疗相比,放疗后3个月有效率和完全缓解率显著提高,不良反应明显降低,患者依从性明显提高,值得进一步研究。Objective To compare the short-term effects of Paclitaxel/Nedaplatin and Cisplatin/5-Fu on weekly concomitant chemoradiotherapy of advanced esophageal cancer. Methods Thirty-six patients with advanced esophageal cancer were divided into TN group（ radiation with weekly concurrent chemotherapy of Paclitaxel / Nedaplatin） and PF group（ radiation with weekly concurrent chemotherapy of Cisplatin /5-Fu）. The short-term effects at the end of the radiotherapy and 3 months after radiotherapy were observed. Results 1At the end of radiotherapy,the overall response rate in TN group and in PF group was 88. 89% and86. 11%. At 3 months after the end of radiotherapy,the overall response rate of the group and the PF group was 91. 67% and69. 44%. The complete remisson rate of TN group and in PF group was 38. 88% and 25. 00%. The complete remission rate of two groups was 69. 44% and 44. 44%（ P = 0. 032）. 2Incidences of peripheral nerves toxicities and leucopenia in TN group were higher than those in PF group,while the patients＇ physical function,role function,emotional function,social function,general health status were better than those in PF group,and treatment symptoms such as fatigue,nausea,vomiting,anorexia and constipation in TN group were less frequent in TN group than in PF group. Conclusion At 3 months after radiotherapy,radiation with weekly concurrent chemotherapy of Paclitaxel / Nedaplatin significantly improves the overall responses and the complete remissions,and reduces the impacts on quality of life at the same time.

关 键 词：食管癌 周剂量同期放化疗 紫杉醇 奈达铂 

分 类 号：R735.1[医药卫生—肿瘤]