侵袭性牙周炎患者龈沟液瘦素水平与牙周临床指标的相关性分析  

Association between gingival crevicular fluid leptin level and periodontal parameters in patients with aggressive periodontitis

作　　者：刘蕴玉[1] 张欣[2] 释栋[2] 陈智滨[2] 孟焕新[2] 

机构地区：[1]北京大学医院口腔中心,100871 [2] 北京大学口腔医学院·口腔医院牙周科,100081

出　　处：《中华口腔医学杂志》2014年第12期733-736,共4页Chinese Journal of Stomatology

基　　金：国家自然科学基金（30973319、81271149）;＂十一五＂国家科技支撑计划（2007BAI18B02）;卫生部临床学科重点项目（2010）

摘　　要：目的 研究侵袭性牙周炎（aggressive periodontitis,AgP）患者龈沟液瘦素水平及其与牙周临床指标之间的相关性,初步探讨牙龈组织中瘦素在牙周炎症发生和发展中的作用.方法 研究对象为54例AgP患者（AgP组）和30名健康对照者（健康对照组）.记录受试者的出血指数、探诊深度、附着丧失等临床指标;选择每位受试者的前牙和后牙各1颗为试验牙,收集每颗牙近中或远中颊侧位点的龈沟液,用酶联免疫吸附测定法检测龈沟液中的瘦素水平.结果 AgP患者的龈沟液瘦素总量为（16.5±4.6） ng,质量浓度[中位数（四分位数间距）]为0.82（0.90） mg/L,均显著低于健康对照组的总量（26.0±6.0） ng和质量浓度13.6（22.15） mg/L,P＜0.05.龈沟液瘦素水平与取样位点的出血指数（r=-0.306,P＜0.01）、探诊深度（r=-0.346,P＜0.01）、附着丧失（r=-0.250,P＜0.01）均呈显著的负相关关系.结论 AgP患者的龈沟液瘦素水平降低;龈沟液瘦素水平与出血指数、探诊深度及附着丧失等指标呈负相关关系.Objective To determine the level of leptin in gingival crevicular fluid （GCF）of patients with aggressive periodontitis （AgP）and to analyze the relationship between leptin and periodontal cilinical parameters.Methods Fifty-four patients with AgP and 30 healthy controls were recruited.Detailed clinical examinations were conducted,and clinical parameters such as bleeding index （BI）,probing depth （PD）,attachment loss （AL）were recorded.Two teeth were selected as test teeth in each subject,one from posterior area and the other from anterior region.The level of GCF leptin was measured by enzyme linked immunosorbent assay.Results The level of GCF leptin in AgP patients was significantly lower than that of control subjects[（16.5±4.6） ng vs.（26.0±6.0） ng,P〈0.05].The level of GCF leptin was negatively related to BI （-0.306,P〈0.01）,PD （-0.346,P〈0.01） and AL （-0.250,P〈0.01）.Conclusions AgP patients have significantly decreased level of GCF leptin and the level of leptin was negatively related to BI,PD and AL.

关 键 词：侵袭性牙周炎 瘦素 附着丧失 

分 类 号：R781.4[医药卫生—口腔医学]