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作 者:丁涛[1] 何小舟[1] 许贤林[1] 徐海燕[1] 周萃星[1] 王禹基[2]
机构地区:[1]苏州大学附属第三医院泌尿外科,江苏常州213003 [2]南京医科大学附属常州第二医院骨科,江苏常州213003
出 处:《中华男科学杂志》2014年第12期1090-1092,共3页National Journal of Andrology
摘 要:目的:探讨卵泡抑素样蛋白1(FSTL1)在前列腺癌骨转移患者中的表达,以及血清FSTL1与机体慢性炎性因子白介素6(IL-6)、细胞生长分化调节相关因子骨形成蛋白6(BMP6)的相关性,探讨血清FSTL1对前列腺癌骨转移的临床应用价值。方法:采用ELISA法测定35例前列腺癌骨转移患者和30例良性前列腺增生(BPH)患者血清FSTL1、IL-6、BMP6水平,并进行相关性分析。结果:前列腺癌骨转移组血清FSTL1的表达水平[(20.23±8.69)μg/L]较BPH组[(35.45±12.35)μg/L]明显降低(P<0.01);血清IL-6、BMP6表达[(23.56±20.17)μg/L、(428.30±178.40)μg/L]较BPH组[(11.21±8.62)μg/L、(293.50±39.72)μg/L]明显增高(P<0.05);前列腺癌骨转移组的血清FSTL1的表达与IL-6、BMP6呈显著负相关,相关系数分别为-0.971、-0.972(P<0.05)。结论:前列腺癌骨转移患者血清FSTL1的表达降低,并且和体内炎症因子、细胞转化因子有关,为临床判断前列腺癌的发生及进展提供了新的生物学标记,为前列腺癌治疗提供了新的生物学靶向分子。Objective : To investigate the expression of follistatin-like protein 1 ( FSTL-1 ) in bone metastasis of prostate cancer (BMPC) , the correlation of serum FSTL-1 with the chronic inflammatory factor interleukin-6 (IL-6) and bone morphogenetic protein 6 (BMP6) , and the clinical application value of serum FSTL-1 in BMPC. Methods : Using ELISA, we measured the expression levels of serum FSTL-I, 1L-6, and BMP6 in 35 patients with BMPC and another 30 with benign prostatic hyperplasia (BPH) and performed correlation analysis on the data obtained. Results: Compared with the BPH controls, the BMPC patients showed a significantly decreased expression of serum FSTL-1 ( [ 34.45 ± 12.35 ] μg/L vs [ 20.23 ± 8.69 ] μg/L, P 〈 0.01 ) and increased levels of IL-6 ( [11.21 ±8.62] μg/L vs [23.56 ±20.12] μg/L, P〈0.05) and BMP6 ( [293.50 ±39.72] μg/L vs [428.30 ±178.40] μg/L, P 〈 0.05 ). There was a significant negative correlation between the level of serum FSTL-1 and those of IL-6 and BMP6 in the BMPC patients, with correlation coefficients of -0. 971 and -0. 972, respectively (P 〈0.05). Conclusion: The expression of serum FSTL-1 decreases in patients with bone metastasis of prostate cancer, and it is correlated with the levels of inflammatory factor and cell transformation factor. This finding offers a novel biological marker for the development and progression of prostate cancer as well as a new biological target factor for its intervention.
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