七叶皂苷钠治疗糖尿病黄斑水肿的疗效观察  

Clinical observation of sodium aescinate for diabetic macular edema

作　　者：付彩云[1] 黄厚斌[1] 

机构地区：[1]解放军总医院眼科,北京市100853

出　　处：《眼科新进展》2014年第12期1141-1143,共3页Recent Advances in Ophthalmology

摘　　要：目的探讨七叶皂苷钠治疗糖尿病黄斑水肿的疗效及安全性,为临床治疗提供一定的参考依据。方法通过光学相干断层扫描检测98例糖尿病黄斑水肿患者服用七叶皂苷钠片治疗前后的黄斑水肿厚度,同时检测不同治疗时间双眼视力,进一步分析其治疗糖尿病黄斑水肿的效果,治疗同时监测患者服药期间不良反应发生情况,评价其安全性。结果 98例患者双眼黄斑水肿厚度与给药前相比,给药结束及停药4周时均明显变薄,差异有显著统计学意义（P〈0.01）,且停药4周时黄斑水肿变薄更明显。其中右眼由给药前（399.7±83.3）μm变薄至停药4周时（319.8±89.4）μm,左眼则由（408.5±87.0）μm变薄至（314.7±86.2）μm。患者裸眼视力及最佳矫正视力均随用药时间逐渐提高,且在给药8~12周时提高较明显,差异有统计学意义（P〈0.05）,其中双眼最佳矫正视力均由给药前的0.4±0.1明显提高至停药4周时的0.7±0.2。服药期间共有16例（16.3%）患者发生胃部不适、恶心等不良反应,2例因反应较重而退出研究,2例（2%）患者症状持续存在,其余均痊愈或留有轻微后遗症。结论七叶皂苷钠片治疗糖尿病黄斑水肿疗效好且安全性高,值得在临床推广应用。Objective To evaluate the effects and safety of sodium aescinate for diabetic macular edema（DME） ,and offer a few bases for clinical therapy. Methods The thickness of macular edema in DME patients （98 cases） were measured by optical coherence tomography（OCT） after treatment with sodium aescinate. Meanwhile the binoculus visual acuity was measured to analyze the effect in different treatment time. Simultaneously, during taking medicine the adverse reactions were monitored to estimate its safety. Results All patients＇ mean thicknesses of macular edema were decreased distinctly at the end and 4 weeks withdrawal,there was statistical difference（P 〈0.01 ）, and the latter was more obvious. And the right eye＇ s mean thicknesses of macular edema was decreased from （399.7 ± 83.3 ） μm in before dosing to （ 319.8 ± 89.4 ） μm in 4 weeks withdrawal,the left eye was decreased from （408.5 ± 87.0）μm to （314. 7 ± 86. 2） μm. Consistent with them, all the patients＇ best corrected visual acuity were increased gradually along with taking medicine, and the increase in 8 - 12 weeks was more evident, there was statistical difference （P 〈 0.05 ）. And both eyes＇ best corrected visual acuity were increased obviously from 0.4 ± 0.1in before dosing to 0.7 ± 0.2 in 4 weeks withdrawal. 16 patients （ 16.3% ） had upset stomach and nausea, but only 2 patients＇ symptom persisted,the others were all cured. Conelusion Sodium aescinate has good curative effect and high safety in treating DME, therefore it deserves to be ap-plied in clinic.

关 键 词：七叶皂苷钠 糖尿病 黄斑水肿 

分 类 号：R774.5[医药卫生—眼科]