MicroRNA-34b/c rs4938723 T>C多态性与中国汉族人群肾细胞癌易感性的相关性  

MicroRNA-34b/c rs4938723 T>C polymorphism is associated with renal cell carcinoma risk in southern Han ethnic Chinese population

作　　者：朱建[1] 李小鑫[1] 张少波[2] 曹强[2] 秦超[2] 李建明[1] 解吕中[1] 殷长军[2] 

机构地区：[1]南通市中医院泌尿外科,江苏南通226001 [2]南京医科大学第一附属医院泌尿外科,江苏南京210029

出　　处：《现代泌尿外科杂志》2014年第11期751-755,共5页Journal of Modern Urology

摘　　要：目的：研究中国汉族人群microRNA‐34b／c启动子区T＞C（rs4938723）多态性与肾细胞癌易感性之间的关系。方法采用病例对照研究模式，通过TaqMan探针PCR法检测年龄和性别匹配的710例中国汉族人群肾细胞癌患者和760例正常人群的microRNA‐34b／c启动子区T＞C（rs4938723）基因型，探讨该位点基因多态性与肾细胞癌易感性之间的关系。结果与 TT／TC基因型携带者相比，CC型（OR＝1．53，95％ CI＝1．06～2．21，CC基因型比TT基因型；OR＝1．48，95％ CI＝1．05～2．10，CC基因型比T T／TC基因型）携带者发生肾细胞癌的危险性明显升高。分层分析显示携带CC基因型的老年患者（OR＝1．80，95％CI＝1．08～3．01）、男性患者（OR＝1．64，95％ CI＝1．08～2．51）、吸烟患者（OR＝2．07，95％ CI＝1．16～3．69）及饮酒患者（OR＝1．94，95％ CI＝1．01～3．73）发生肾细胞癌的危险性明显升高。结论 microRNA‐34b／c启动子区T＞C（rs4938723）基因多态性与我国汉族人群肾细胞癌易感性有关，CC型携带者发生肾细胞癌的危险性要明显高于T T／TC型携带者。Objective To evaluate the relationship between the microRNA‐34b/c promoter region T〉C （rs4938723） pol‐ymorphism and renal cell carcinoma risk （RCC ） in southern Han ethnic Chinese population .Methods The rs4938723 was genotyped using TaqMan method to explore the relationship between this polymorphism and the risk of RCC in a case‐control study of 710 RCC patients and 760 control subjects .Results Individuals carrying the CC genotype had a significantly in‐creased RCC risk [odds ratio （OR）=1 .53 ,95% confidence interval （CI）=1 .06~2 .21 for CC vs .TT ,and OR=1 .48 ,95%CI=1 .05~2 .10 for CC vs .TT/TC ,respectively] compared with those with TT or TT/TC genotypes .Furthermore ,the in‐creased risk was more evident in the subgroups of older subjects （OR=1 .80 ,95% CI=1 .08~3 .01） ,males （OR=1 .64 ,95%CI=1 .08~2 .51） ,smokers （OR=2 .07 ,95% CI=1 .16~3 .69） and drinkers （OR=1 .94 ,95% CI=1 .01~3 .73） .Conclu‐sion These results suggest that the microRNA‐34b/c rs4938723 C allele may increase the susceptibility to RCC by decreasing the activity of microRNA‐34b/c promoter compared with T allele .

关 键 词：肾细胞癌 微小RNA-34b/c 单核苷酸多态性 遗传易感性 

分 类 号：R737[医药卫生—肿瘤]