急性脑梗死患者外周血T、B淋巴细胞亚群和NK细胞的变化  

Changes of blood lymphocyte subgroup in patients with acute cerebral infarction

作　　者：杨金伟[1] 田朝晖[2] 韩呈武[1] 于雪莹[1] 曹永彤[1] 

机构地区：[1]中日友好医院检验科,北京100029 [2]中日友好医院神经内科,北京100029

出　　处：《中日友好医院学报》2014年第6期331-333,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨急性脑梗死患者外周血T、B淋巴细胞亚群和自然杀伤细胞(NK细胞)数量的变化及其临床意义。方法:用流式细胞仪直接荧光抗体染色法检测29例急性脑梗死患者和29例体检健康人员的外周血CD3+(T)%、CD3+CD4+(Th)%、CD3+CD8+(Ts)%、Th/Ts、CD16+56+(NK)%、CD19+CD5+(B1)%和CD19+CD5-(B2)%。结果:急性脑梗死患者发病后外周血Th%、Th/Ts和B2%的均值较正常对照组显著升高(P<0.05);Ts%和NK%的均值较正常对照组显著降低(P<0.05)。结论:急性脑梗死患者发病初期,T淋巴细胞总数较正常人群低,Th/Ts较正常对照高;B淋巴细胞总数较正常人群高,B2比B1升高更多;NK细胞较正常人群低。Objective：To explore the changes of lymphocyte subgroup in the peripheral blood in patients with acute cerebral infarction （ACI）.Methods ：The percentage of CD3＋（T）, CD3＋CD4＋（Th）, CD3 ＋CD8 ＋（Ts）,Th/Ts , CD16＋56＋（NK）,CD19＋CD5＋（B1）and CD19＋CD5-（B2）in peripheral blood were examined with flow cytometry in 29 patients with acute cerebral infarction and 29 healthy controls （control group ） .Results ： The percentage of Th,B2 and Th/Ts in patients with ACI were significantly higher than those in the control group （P〈0.05）.Ts% and NK% in patients with ACI were significantly lower than those in control group （P〈0.05）.Conclusion：In patients with ACI,the percentage of Th/Ts and B cells are higher than the control group,and percentage of B2 is higher than Bl.In contrast,T cells and NK cells in patients with ACI are lower than those in the con- trol.

关 键 词：脑梗死 淋巴细胞亚群 流式细胞术 

分 类 号：R743.33[医药卫生—神经病学与精神病学]