放射性心脏损伤动物模型的研究进展  

Progress in animal model of radiation-induced heart disease

作　　者：张洪明[1] 李险峰[1] 

机构地区：[1]山西医科大学第一医院放疗科,太原030001

出　　处：《国际放射医学核医学杂志》2014年第6期412-415,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81371600）;山西医科大学科技创新基金（057279）

摘　　要：目前我国肿瘤发病率已超越心血管疾病跃居第一位,随着外科及放化疗技术的提升与发展,肿瘤患者的生存周期已得到大幅度提高.与之相反的是肿瘤在治疗过程中所引起的近期和远期并发症却已成为影响患者生存质量的主要因素,尤其是胸廓、胸壁及纵隔肿瘤（如霍奇金淋巴瘤、乳腺癌等）在进行放疗时所引起的心脏的近期及远期不良反应,成为该类肿瘤患者死亡的重要原因之一.而稳定的动物模型是临床前研究放射性心脏损伤的基础,为放射性心脏损伤的预防和治疗提供大量实验依据.为此该文对历年来研究者常用建立放射性心脏损伤模型的造模动物及其特点、造模方法的改进与发展、模型的具体应用进行综述.The incidence of cancer has surpassed the cardiovascular disease as the first one in China.With the improvement and development of surgical techniques and chemo-radiotherapy,the patient＇s survival time has been prolonged greatly.On the contrary,long-term and recent complications caused during the tumors treatment process have become one of the main factors which severely influence the quality of life of the patients.Cardiovascular recent and long-term adverse reaction caused by radiation has become the major cause of death in cancer patients especially for thoracic,chest wall and mediastinal tumor （such as Hodgkin＇s lymphoma,breast cancer,etc.）.And stable animal model is the basis of clinical research of radioactive heart damage which can provide a large number of experiments for the prevention and treatment of radioactive heart damage.For this purpose,the article reviewed the animal model of radioactive heart damage and its characteristics,the improvement and development of the modelling methods,and the concrete application of the model.

关 键 词：辐射损伤 心脏损伤 模型 动物 

分 类 号：R730.55[医药卫生—肿瘤] R-332[医药卫生—临床医学]