调控成骨细胞分化及骨形成关键信号通路的研究进展  

RESEARCH PROGRESS OF KEY SIGNALING PATHWAYS IN OSTEOBLAST DIFFERENTIATION AND BONE FORMATION REGULATION

作　　者：徐练[1] 孔清泉[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2014年第12期1484-1489,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81171731)~~

摘　　要：目的综述在成骨细胞分化及骨形成过程中起关键调节作用的相关信号通路作用机制及研究进展。方法查阅近年来与成骨细胞分化及骨形成信号通路相关的文献,并进行综合分析。结果目前已发现多条信号通路参与了成骨细胞分化及骨形成的调节,其中BMP-Smads、Wnt/β-catenin、Notch、Hedgehog、FGF信号通路的作用最关键。这些信号通路不但自身具有较复杂的调控机制,而且彼此相互联系、相互影响,从而组成了一个更复杂而精细的调控网络,共同参与成骨细胞分化及骨形成的调节。然而,由于相关动物实验技术不成熟,临床试验研究较少,其详细作用机制体系仍不十分明了。结论对成骨相关信号通路的进一步深入研究,将有望彻底揭开成骨细胞分化及骨形成过程的完整分子机制,从而为临床有效防治成骨分化及骨形成异常性疾病提供理论依据。Objective To review the mechanism and research progress of signaling pathways which play key roles in the regulation of osteoblast differentiation and bone formation.Methods Recent articles about signaling pathways of osteoblast differentiation and bone formation were reviewed and comprehensively analyzed.Results At present,multiple signaling pathways have been found to be involved in the regulation of osteoblast differentiation and bone formation,among which bone morphogenetic protein-Smads,Wnt/p-catenin,Notch,Hedgehog,and fibroblast growth factor signaling pathways may play the most important roles.Not only each pathway has a complex regulatory mechanism itself,but also contacts and impacts with each other,thus they formed a more complicated and sophisticated regulatory network,and regulate together osteoblast differentiation and bone formation.However,the mechanisms in detail of those pathways are still not very clear,because the animal experiment techniques are not yet mature as well as the relevant clinical trials were carried out not too much.Conclusion The complete molecular mechanism of osteoblast differentiation and bone formation should be further investigated,so as to lay a theory foundation for preventing and treating the common bone diseases in clinical which are involve in osteoblast differentiation and bone formation.

关 键 词：MSCS 成骨细胞分化 骨形成 信号通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]