三尖杉酯碱和BCNU脑血管内化疗治疗恶性脑瘤的疗效比较  

Efficacy comparison of three harringtonine and cerebrovascular BCNU chemotherapy treatment of malignant brain tumors

作　　者：程杨玉 任宇红 樊文彦 匡国鹏 冯照东 闫二军 杨永飞 张永清 王丽芳 申惠芳 王婷婷 王丹丹 

机构地区：[1]山西省长治市第二人民医院神经外科,046000

出　　处：《中国实用医刊》2015年第2期28-29,共2页Chinese Journal of Practical Medicine

摘　　要：目的 比较三尖杉酯碱和BCNU脑血管内化疗治疗恶性肿瘤的临床效果.方法 随机选取2009年3月至2011年6月在长治市第二人民医院进行恶性肿瘤治疗的19例患者为观察对象,对其临床资料进行回顾性分析.选取其中10例采用三尖杉酯碱进行治疗的患者作为试验组,另9例采用BNCU脑血管内化疗法的患者作为对照组,两组患者在年龄、性别、病情等方面比较差异无统计学意义（P＞0.05）.比较两组在治疗效果、并发症发生以及患者生命延长时间等方面的差异.结果 对照组6例治疗有效,治疗有效率为66.67％,试验组7例治疗有效,治疗有效率为70％,两组比较差异无统计学意义（P＞0.05）.对照组平均生命延长时间为18.5个月,试验组为22.3个月,差异有统计学意义（P＜0.05）结论 三尖杉酯碱较BNCU脑血管内化疗治疗恶性肿瘤效果明显,更能延长患者的生命时间,可以在临床中推广应用.Objective To compare the clinical effects of three harringtonine and chemotherapy on cerebral vascular BCNU malignancies.Methods From March 2009 to June 2011,in the second people＆#39;s hospital of Changzhi,19 patients with cancer treatment were analyzed retrospectively.Ten patients underwent treatment with three harringtonine as the experimental group,and the other 9 cases were treated with chemotherapy within BNCU cerebrovascular as the control group,the differences of the two groups in age,gender,disease and other aspects were not obvious,there was no significant difference （P 〉 0.05）.The complications and prolong the lives of patients differences in terms of time was compared.Results There were 6 patients with effective results in the control group,the treatment effective rate was 66.67%,and 7 patients were effective in the test group,the treatment effective rate was 70%,treatment efficiency difference was not statistically significant （P 〉 0.05）.The average life extension of time in the control group was 18.5 months,the average life span of patients was 22.3 months.The average life span had obvious difference with statistical significance （P 〈 0.05）.Conclusions Three harringtonine in the treatment of malignant tumors has good cerebrovascular chemotherapy effects,can prolong the life time of the patient,so it can be used in clinical practice.

关 键 词：三尖杉酯碱 BCNU脑血管内化疗 恶性肿瘤 治疗效果 

分 类 号：R739.410.5[医药卫生—肿瘤]