前列腺癌组织Clusterin与Survivin表达与PSA的相关性分析  

The correlation of PSA and expression of Clusterin and Survivin in prostate cancer tissue

作　　者：王超奇[1,2] 侯建全[1] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]内蒙古民族大学附属医院,内蒙古通辽028007

出　　处：《现代肿瘤医学》2015年第1期77-79,共3页Journal of Modern Oncology

基　　金：内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(编号:201303103)

摘　　要：目的:分析蛋白Clusterin和Survivin在前列腺癌(PCa)组织中的表达与前列腺特异性抗原(PSA)的相关性及在前列腺癌诊断中的应用价值。方法:应用免疫组织化学方法检测80例前列腺癌和50例前列腺增生组织凋亡蛋白Clusterin、Survivin的表达和相应患者血浆中PSA值。结果:前列腺癌组织中Clusterin、Survivin蛋白的阳性表达率分别为57.5%(46/80)、48.8%(39/80),Clusterin和Survivin蛋白在前列腺增生组织中的阳性表达率分别为0(0/50)、0(0/50),差异具有统计学意义(P<0.05)。Clusterin和Survivin蛋白表达与前列腺癌病理分级、临床分期、转移情况和PSA具有相关性(P<0.05),前列腺癌组织中Survivin与Clusterin的表达无相关性(P>0.001)。结论:联合检测Clusterin及Survivin表达与前列腺特异抗原(PSA)可为前列腺癌的防治和治疗提供新的思路。Objective：To study the correlation of PSA and expression of Clusterin and Survivin in prostate cancer tissue. Methods：Immunohistochemistry was employed to measure the expression of Clusterin and Survivin in 80 cases of prostatic cancer and 50 cases of benign prostatic hyperplasia（ BPH）and PSA in plasma. Results：In prostatic canc-er tissue,the positive expression rates of Clusterin and Survivin were 57. 5%（46/80）and 48. 8%（39/80）. In be-nign prostatic hyperplasia tissue ,the positive expression rates of Clusterin and Survivin were 0（ 0/50 ）,0（ 0/50 ） （ p〈0. 05）. The positive expression of Clusterin and Survivin were related with the histologic grade,clinical stage and metastasis of prostatic cancer and PSA（p〈0. 05）. The expression of Survivin was not correlated with Clusterin ex-pression in prostatic cancer（p〉0. 001）. Conclusion：The expression of Clusterin and Survivin and PSA in PCa may offer a new mode for the prevention and treatment of prostatic cancer.

关 键 词：前列腺癌 CLUSTERIN SURVIVIN PSA 

分 类 号：R737.25[医药卫生—肿瘤]