AFP、CEA检测对良恶性腹腔积液的诊断价值  

Diagnostic value of AFP,CEA for differentiating benign and malignant ascites

作　　者：刘玉军 吴敏慧 

机构地区：[1]榆林市神木县医院检验科,陕西榆林719300 [2]陕西省肿瘤医院中西医结合科,陕西西安710061

出　　处：《现代肿瘤医学》2015年第2期232-234,共3页Journal of Modern Oncology

摘　　要：目的:探讨腹腔积液患者甲胎蛋白(alpha-fetoprotein,AFP)、癌胚抗原(carcinoembryonic antigen,CEA)表达水平对良恶性腹腔积液的诊断价值。方法:回顾性分析本院97例腹腔积液患者的临床资料,按照腹腔积液性质分为良性组42例和恶性组55例,应用罗氏Cobas E601全自动电化学发光免疫分析仪检测并比较两组患者血清和腹腔积液中AFP、CEA的测定结果。结果:恶性腹腔积液组血清和腹腔积液表达均显著高于良性腹腔积液组的表达(P<0.05);恶性腹腔积液组AFP和CEA的腹腔积液/血清比值显著高于良性组(P<0.05);腹腔积液AFP和CEA的表达同血清中的表达比较具有显著性差异(P<0.05)。单项肿瘤标志物检测腹腔积液AFP检测的准确度最高,两项指标联合检测腹腔积液检测的准确度高于血清检测的准确度(P<0.05)。结论:检测腹腔积液患者AFP、CEA表达水平有助于积液性质的良恶性鉴别;腹腔积液AFP、CEA的检测对恶性腹腔积液的诊断较血清学检测更有价值;肿瘤标志物联合检测能提高恶性腹腔积液诊断的准确度。Objective：To investigate expression levels of AFP,CEA in patients with seroperitoneum and to evaluate their diagnostic value for differentiating malignant and benign seroperitoneum.Methods：Clinical data of 97 cases of abdominal effusions were analyzed retrospectively and in accordance with the nature of ascites,they were divided into 42 cases of benign group and 55 cases of malignant group.Apply Roche Cobas E601 fully automatic electrochemiluminescence immunoassay analyzer to detect and compare serum and abdominal effusions AFP,CEA concentration.Results：Serum and abdominal effusions AFP,CEA expression were significantly higher in the patients with malignant abdominal effusions than those with benign abdominal effusions （P ＜ 0.05）.The abdominal effusions/serum （AFP,CEA） were significantly higher in the patients with malignant abdominal effusions than those with benign abdominal effusions （P ＜ 0.05）.The AFP,CEA expression in abdominal effusions were significantly higher than in serum （P ＜ 0.05）.To detect CEA expression in abdominal effusions is the higher accurable than the others single tumor mark detection,the accuracy of AFP and CEA combined measurement in abdominal effusions was higher than serum detection.Conclusion：To detect AFP,CEA expression in the patients with seroperitoneum was helpful for differentiating malignant and benign seroperitoneum.Abdominal effusion AFP,CEA expression is more valuable on malignant abdominal effusions diagnosis than serological test.Multiple tumor markers combined measurement can improve the diagnosis accuracy of malignant ascites.

关 键 词：腹腔积液 甲胎蛋白 癌胚抗原 电化学发光免疫分析技术 

分 类 号：R730[医药卫生—肿瘤]