血清淀粉样蛋白酶P(SAP)在3种常见结缔组织病患者中的表达及其意义  

Significance and Levels of Serum Amyloid P Component in Three Common Connective Tissue Diseases' Patients

作　　者：吴丽芬[1] 范倩[1] 陈风华[2] 孙文闻[1] 刘永玉[1] 姬海燕[1] 魏蔚[1] 巩路[1] 

机构地区：[1]天津医科大学总医院,天津300052 [2]中国人民解放军第二炮兵总医院

出　　处：《中国医学创新》2014年第30期124-126,共3页Medical Innovation of China

基　　金：天津市卫生局科技基金项目(2013KZ123)

摘　　要：目的:研究血清淀粉样蛋白P(SAP)在3种常见结缔组织病患者血清中含量,探讨其在结缔组织病发生发展中的作用及意义。方法:用ELISA方法测定正常人、系统性红斑狼疮活动期和缓解期、类风湿关节炎活动期和缓解期、初治干燥综合征等风湿性疾病血清中血清淀粉样蛋白P(SAP)含量。统计各型患者血清中血清淀粉样蛋白P(SAP)的表达水平及其意义。结果:SAP在系统性红斑狼疮患者活动期血清中高表达,且其表达水平显著高于缓解期和正常人,差异均有统计学意义(P<0.05)。结论:血清淀粉样蛋白P(SAP)在系统性红斑狼疮活动期高表达,可以作为系统性红斑狼疮患者活动期的诊断指标之一。Objective：To investigate the expression levels of Serum amyloid P（SAP）and its clinical significance in three common connective tissue diseases’ patients.Method：The expressions of SAP in serum were analyzed by enzyme linked immunosorbent assay（ELISA）in healthy persons,SLE patients with active disease and remission disease, rheumatoid arthritis patients with active disease and remission disease,sjogren’s syndrome with first treatment. Then statistical analysis was used for them.Result：SAP in patients with SLE activity has a high expression,and its expression level was significantly higher than that of remission and normal people,the differences were statistically significant （P〈0.05）.Conclusion：SAP is increased in SLE patients with active disease,and it can be used as one of the diagnostic index of the activity in SLE patients with active disease.

关 键 词：血清淀粉样蛋白酶P(SAP) 系统性红斑狼疮 类风湿关节炎 干燥综合征 Serum amyloid P component(SAP) Systemic LUPUS erythematosus(SLE) RHEUMATOID arthritis(RA) Primary sjogren’s syndrome(PSS) 

分 类 号：R593.2[医药卫生—内科学]