慢性应激介导的神经内分泌和免疫系统变化及对肿瘤的影响  

The Changes of Neuroendocrine and Immune System Mediated by Chronic Stress and the Influences on Tumor

作　　者：李密辉 董竞成[1] 

机构地区：[1]复旦大学附属华山医院中西医结合科,上海200032

出　　处：《医学综述》2014年第23期4225-4228,共4页Medical Recapitulate

基　　金：国家973课题(2009CB523001);国家自然科学基金(81173390;81102562)

摘　　要：随着现代社会生活节奏的不断加快,个体承受的压力不断增加,表现为焦虑、紧张、失眠、抑郁甚至是疾病,这些因素都使机体处于一种慢性应激状态。慢性应激与神经内分泌免疫网络失衡甚至肿瘤疾病的发生、进展都有密切的关系,明确这一网络中各途径之间的关系,可为干预肿瘤提供新思路和新靶点。该文就慢性应激与下丘脑-垂体-肾上腺皮质轴、交感神经系统和免疫系统的关系及其对肿瘤发生和进展的影响予以综述。With the ever-increasing pace of modem life, the individual bears more pressure and shows anxiety, tension, insomnia, depression, even diseases. These factors make body in chronic stress state. Chronic stress is closely related with the imbalance of neural-endocrine-immune network and even tumor. Therefore a better understanding of the paths in the network can provide us more new thoughts and therapeutic targets to intervene tumor. Here is to make a review of the correlation of chronic stress with the hypothalamic-pituitaryadrenal axis, sympathetic nervous system and the immune system, and its influence on the onset and development of tumors.

关 键 词：慢性应激 下丘脑-垂体-肾上腺皮质轴 交感神经系统 免疫系统 肿瘤 

分 类 号：R73[医药卫生—肿瘤]