DNA异常甲基化在胃癌中的研究进展  

Research Progress of Aberrant DNA Methylation in Gastric Cancer

作　　者：孙婧悦 何敬东[1] 

机构地区：[1]南京医科大学附属淮安第一医院肿瘤科,江苏淮安223300

出　　处：《医学综述》2014年第23期4267-4268,4274,共3页Medical Recapitulate

基　　金：江苏省卫生厅医学科技发展基金(H201358)

摘　　要：胃癌是最常见的恶性肿瘤之一,也是世界范围内癌症相关死亡的主要原因,其发生是由多因素参与的多阶段病理过程。近年来,随着对胃癌研究的不断深入,表观遗传学逐渐成为研究热点。表观遗传学改变包括DNA甲基化、组蛋白变体、基因组印记的缺失等,其中胃癌相关基因的异常甲基化最为重要,其改变能使抑癌基因失活、原癌基因激活,在胃癌的发生、发展中起着重要的作用。Gastric cancer is one of the most common malignancies, and a primary reason of cancer mortality worldwide. Multiple factors are involved in the muhi-stage pathological process of carcinoma. With the deepening study of gastric cancer, epigenetics is becoming a research hotspot. The epigenetic alterations include DNA methylation, histone modifications and genomic imprinting deletion, among which the DNA aberrant methylation of gastric cancer-related genes is most important, since it leads to inactivation of tumor suppressor genes and activation of oncogenes,playing a significant role in cancer initiation and progression.

关 键 词：DNA甲基化 胃癌 抑癌基因 

分 类 号：R735.2[医药卫生—肿瘤]